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penkb proenkephalin b [ Danio rerio (zebrafish) ]

Gene ID: 360136, updated on 2-Nov-2024

Summary

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Official Symbol
penkbprovided by ZNC
Official Full Name
proenkephalin bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030729-3
See related
Ensembl:ENSDARG00000036045 AllianceGenome:ZFIN:ZDB-GENE-030729-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
penk
Summary
Predicted to enable opioid receptor binding activity. Predicted to be involved in chemical synaptic transmission; neuropeptide signaling pathway; and sensory perception. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon terminus; dendrite; and neuronal cell body. Is expressed in central nervous system; neurons; and pronephric duct. Human ortholog(s) of this gene implicated in overactive bladder syndrome. Orthologous to human PENK (proenkephalin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See penkb in Genome Data Viewer
Location:
chromosome: 7
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (58686858..58696086)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (58379106..58393586)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 7, subfamily A, polypeptide 1b Neighboring gene uncharacterized LOC137496227 Neighboring gene short chain dehydrogenase/reductase family 16C, member 5b Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Trends in the evolution of the proenkephalin and prodynorphin genes in gnathostomes. Khalap A, et al. Ann N Y Acad Sci, 2005 Apr. PMID 15891003
  2. Phylogenetic diversity and functional efficacy of the C-terminally expressed heptapeptide unit in the opioid precursor polypeptide proenkephalin A. Bojnik E, et al. Neuroscience, 2011 Mar 31. PMID 21241776
  3. Characterization of zebrafish proenkephalin reveals novel opioid sequences. Gonzalez Nuñez V, et al. Brain Res Mol Brain Res, 2003 May 26. PMID 12782390
  4. In vivo regulation of the μ opioid receptor: role of the endogenous opioid agents. Gonzalez-Nunez V, et al. Mol Med, 2013 Mar 5. PMID 23348513, Free PMC Article
  5. Evaluation of the Antiseizure Activity of Endemic Plant Halfordia kendack Guillaumin and Its Main Constituent, Halfordin, on a Zebrafish Pentylenetetrazole (PTZ)-Induced Seizure Model. Skiba A, et al. Int J Mol Sci, 2023 Jan 30. PMID 36768918, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
proenkephalin b
Names
PENKa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423597.1 → NP_001410526.1  proenkephalin b precursor

    Status: VALIDATED

    Source sequence(s)
    BX323844
    UniProtKB/TrEMBL
    Q6DBV3, Q7T3L0
    Related
    ENSDARP00000052331.4, ENSDART00000052332.5

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    58686858..58696086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182883.1: Suppressed sequence

    Description
    NM_182883.1: This RefSeq was removed because currently there is insufficient support for the transcript
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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