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IL12RB2 interleukin 12 receptor subunit beta 2 [ Homo sapiens (human) ]

Gene ID: 3595, updated on 14-Nov-2024

Summary

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Official Symbol
IL12RB2provided by HGNC
Official Full Name
interleukin 12 receptor subunit beta 2provided by HGNC
Primary source
HGNC:HGNC:5972
See related
Ensembl:ENSG00000081985 MIM:601642; AllianceGenome:HGNC:5972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Broad expression in placenta (RPKM 2.3), brain (RPKM 0.9) and 18 other tissues See more
Orthologs
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Genomic context

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See IL12RB2 in Genome Data Viewer
Location:
1p31.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (67307364..67398724)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (67181083..67276270)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (67773047..67864407)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U4atac small nuclear 4, pseudogene Neighboring gene DNAJB6 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 980 Neighboring gene NANOG hESC enhancer GRCh37_chr1:67784539-67785040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1177 Neighboring gene RNA, U6 small nuclear 387, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:67894622-67895258 Neighboring gene SERPINE1 mRNA binding protein 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:67895894-67896529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1180 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:67924294-67925217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:67926895-67927395 Neighboring gene MPRA-validated peak278 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:67943422-67943604 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:67945137-67945276 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:67965969-67966472 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:67980737-67981378 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:67981379-67982018 Neighboring gene long intergenic non-protein coding RNA 1702

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A role for IL-12 receptor expression and signal transduction in host defense in leprosy. Kim J, et al. J Immunol, 2001 Jul 15. PMID 11441083
  2. Autoimmune risk loci of IL12RB2, IKZF1, XKR6, TMEM39A and CSK in Chinese patients with systemic lupus erythematosus. You Y, et al. Tissue Antigens, 2015 Mar. PMID 25720506
  3. Mutations of the IL-12 receptor beta2 chain gene in atopic subjects. Matsui E, et al. Biochem Biophys Res Commun, 1999 Dec 20. PMID 10600539
  4. Polymorphisms assessment in the promoter region of IL12RB2 in Amazon leprosy patients. Silva GA, et al. Hum Immunol, 2014 Jun. PMID 24486579
  5. Differential expression and function of human IL-12Rβ2 polymorphic variants. de Paus RA, et al. Mol Immunol, 2013 Dec. PMID 23911393

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association between gene polymorphisms of IL-12, IL-12 receptor and IL-27 and organ involvement in Iranian endometriosis patients.
    Title: Association between gene polymorphisms of IL-12, IL-12 receptor and IL-27 and organ involvement in Iranian endometriosis patients.
  2. Role of Genetic Polymorphisms in IL12Rbeta2 in Chronic Obstructive Pulmonary Disease.
    Title: Role of Genetic Polymorphisms in IL12Rβ2 in Chronic Obstructive Pulmonary Disease.
  3. Expressions of IL-12 and its receptors in patients with lumbar disc herniation and their relationship with clinical efficacy.
    Title: Expressions of IL-12 and its receptors in patients with lumbar disc herniation and their relationship with clinical efficacy.
  4. Mutation analysis showed three previously reported mutations, two novel mutations in IL-12 R (beta1/beta2), and one previously reported mutation in IL-12 Mendelian Susceptibility to Mycobacterial Disease patients.
    Title: Characterization of two novel mutations in IL-12R signaling in MSMD patients.
  5. we analyzed common variants located in genes of the IL12/STAT4 and IL10/STAT3 signaling pathways in patients with myasthenia gravis.
    Title: Evidence for association of STAT4 and IL12RB2 variants with Myasthenia gravis susceptibility: What is the effect on gene expression in thymus?
  6. The Cox proportional hazard models revealed that IL12Rb2 and p38MAPK predicted a long OS. To the best of our knowledge, the present study is the first to reveal a close association between IL12Rb2 and p38MAPK, and their possible function in nonsmall cell lung cancer progression
    Title: The close association between IL‑12Rβ2 and p38MAPK, and higher expression in the early stages of NSCLC, indicates a good prognosis for survival.
  7. Tumor cell differentiation is associated with TILs' expression of IL-12Rbeta2, and an IL-12Rbeta2(+) TIL ratio >/=35%) indicates favorable prognosis in LC
    Title: A high ratio of IL-12Rβ2-positive tumor-infiltrating lymphocytes indicates favorable prognosis in laryngeal cancer.
  8. inhibition of the H3K27 demethylase JMJD3 in naive CD4 T cells demonstrates how critically important molecules required for T cell differentiation, such as JAK2 and IL12RB2, are regulated by H3K27me3.
    Title: H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3.
  9. this study identified susceptibility single nucleotide polymorphisms in IL12RB2 with Behcet's disease in Han Chinese
    Title: Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese.
  10. In ankylosing spondylitis, conditional analysis identified rs11209032 as the probable causal single-nucleotide polymorphism within a 1.14 kb putative enhancer between IL23R and IL12RB2. The rs11209032 single-nucleotide polymorphism downstream of IL23R forms part of an enhancer, allelic variation of which may influence Th1-cell numbers.
    Title: An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
EBI GWAS Catalog
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
EBI GWAS Catalog
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
EBI GWAS Catalog
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coreceptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-12-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-12 receptor subunit beta-2
Names
IL-12 receptor subunit beta-2
IL-12R subunit beta-2
interleukin 12 receptor, beta 2
interleukin-12 receptor beta-2 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032977.2 RefSeqGene

    Range
    5523..96374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_707

mRNA and Protein(s)

  1. NM_001258214.1 → NP_001245143.1  interleukin-12 receptor subunit beta-2 isoform b precursor

    See identical proteins and their annotated locations for NP_001245143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. Variants 2 and 7 encode the same isoform (b), which has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK294494, AL358512, AL389925, DA223630, DB126833, U64198
    Consensus CDS
    CCDS58006.1
    UniProtKB/TrEMBL
    B4DGA4, B7ZB60
    Related
    ENSP00000360039.1, ENST00000371000.5
    Conserved Domains (3) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:127 → 179
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001258215.1 → NP_001245144.1  interleukin-12 receptor subunit beta-2 isoform c precursor

    See identical proteins and their annotated locations for NP_001245144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL358512, AL389925, BC143249, DB126833, U64198
    Consensus CDS
    CCDS58007.1
    UniProtKB/Swiss-Prot
    Q99665
    Related
    ENSP00000442443.1, ENST00000544434.5
    Conserved Domains (3) summary
    cd00063
    Location:423 → 529
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:127 → 179
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. NM_001258216.1 → NP_001245145.1  interleukin-12 receptor subunit beta-2 isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL358512, AL389925, BC143250, DB126833, U64198
    Consensus CDS
    CCDS72805.1
    UniProtKB/TrEMBL
    A0A8Q3SIS8, A0A8Q3SIX0
    Related
    ENSP00000512853.1, ENST00000696755.1
    Conserved Domains (3) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:127 → 179
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. NM_001319233.1 → NP_001306162.1  interleukin-12 receptor subunit beta-2 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. Variants 2 and 7 encode the same isoform (b), which has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK294494, AK316525, AL358512, AL389925, BC143248, U64198
    Consensus CDS
    CCDS58006.1
    UniProtKB/TrEMBL
    B4DGA4, B7ZB60
    Conserved Domains (3) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:127 → 179
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. NM_001374259.2 → NP_001361188.1  interleukin-12 receptor subunit beta-2 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AL358512, AL389925
    Consensus CDS
    CCDS638.1
    UniProtKB/Swiss-Prot
    B1AN98, B7ZKL9, F5H7L6, Q2M3V3, Q99665
    Related
    ENSP00000501329.1, ENST00000674203.2
    Conserved Domains (2) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain

  6. NM_001559.3 → NP_001550.1  interleukin-12 receptor subunit beta-2 isoform a precursor

    See identical proteins and their annotated locations for NP_001550.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL358512, AL389925
    Consensus CDS
    CCDS638.1
    UniProtKB/Swiss-Prot
    B1AN98, B7ZKL9, F5H7L6, Q2M3V3, Q99665
    Related
    ENSP00000262345.1, ENST00000262345.5
    Conserved Domains (2) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain

RNA

  1. NR_047583.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon and lacks another alternate coding exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be non-protein coding.
    Source sequence(s)
    AL358512, AL389925, BC143248, DB126833, U64198

  2. NR_047584.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be non-protein coding.
    Source sequence(s)
    AL358512, AL389925, BC143252, DB126833, U64198

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    67307364..67398724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541384.3 → XP_011539686.1  interleukin-12 receptor subunit beta-2 isoform X2

    Conserved Domains (3) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:127 → 179
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_006710617.3 → XP_006710680.1  interleukin-12 receptor subunit beta-2 isoform X3

    See identical proteins and their annotated locations for XP_006710680.1

    UniProtKB/Swiss-Prot
    Q99665
    Conserved Domains (3) summary
    cd00063
    Location:423 → 529
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:127 → 179
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_005270827.3 → XP_005270884.1  interleukin-12 receptor subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_005270884.1

    UniProtKB/Swiss-Prot
    B1AN98, B7ZKL9, F5H7L6, Q2M3V3, Q99665
    Related
    ENSP00000497959.1, ENST00000648487.1
    Conserved Domains (2) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain

  4. XM_017001203.2 → XP_016856692.1  interleukin-12 receptor subunit beta-2 isoform X4

    UniProtKB/TrEMBL
    B4DGA4, B7ZB60
    Related
    ENSP00000512854.1, ENST00000696757.1
    Conserved Domains (3) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:127 → 179
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. XM_047419665.1 → XP_047275621.1  interleukin-12 receptor subunit beta-2 isoform X2

  6. XM_047419669.1 → XP_047275625.1  interleukin-12 receptor subunit beta-2 isoform X5

    Related
    ENSP00000445276.3, ENST00000541374.6

  7. XM_005270828.4 → XP_005270885.1  interleukin-12 receptor subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_005270885.1

    UniProtKB/Swiss-Prot
    B1AN98, B7ZKL9, F5H7L6, Q2M3V3, Q99665
    Conserved Domains (2) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain

  8. XM_047419668.1 → XP_047275624.1  interleukin-12 receptor subunit beta-2 isoform X4

  9. XM_047419666.1 → XP_047275622.1  interleukin-12 receptor subunit beta-2 isoform X2

  10. XM_047419667.1 → XP_047275623.1  interleukin-12 receptor subunit beta-2 isoform X3

  11. XM_011541383.3 → XP_011539685.1  interleukin-12 receptor subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_011539685.1

    UniProtKB/Swiss-Prot
    B1AN98, B7ZKL9, F5H7L6, Q2M3V3, Q99665
    Conserved Domains (2) summary
    cd00063
    Location:423 → 511
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:28 → 110
    Lep_receptor_Ig; Ig-like C2-type domain

  12. XM_047419670.1 → XP_047275626.1  interleukin-12 receptor subunit beta-2 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    67181083..67276270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336407.1 → XP_054192382.1  interleukin-12 receptor subunit beta-2 isoform X1

    UniProtKB/Swiss-Prot
    B1AN98, B7ZKL9, F5H7L6, Q2M3V3, Q99665

  2. XM_054336408.1 → XP_054192383.1  interleukin-12 receptor subunit beta-2 isoform X1

    UniProtKB/Swiss-Prot
    B1AN98, B7ZKL9, F5H7L6, Q2M3V3, Q99665

  3. XM_054336410.1 → XP_054192385.1  interleukin-12 receptor subunit beta-2 isoform X2

  4. XM_054336409.1 → XP_054192384.1  interleukin-12 receptor subunit beta-2 isoform X1

    UniProtKB/Swiss-Prot
    B1AN98, B7ZKL9, F5H7L6, Q2M3V3, Q99665

  5. XM_054336411.1 → XP_054192386.1  interleukin-12 receptor subunit beta-2 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99665.1 GenPept UniProtKB/Swiss-Prot:Q99665

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