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Hydr1 alpha/beta hydrolase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35930, updated on 2-Nov-2024

Summary

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Official Symbol
Hydr1provided by FlyBase
Official Full Name
alpha/beta hydrolase 1provided by FlyBase
Primary source
FLYBASE:FBgn0033382
Locus tag
Dmel_CG8058
See related
AllianceGenome:FB:FBgn0033382
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8058; Dm.HYDR1; Dmel\CG8058
Summary
Predicted to enable acetylesterase activity and monoacylglycerol lipase activity. Predicted to be involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Is expressed in adult head. Orthologous to human ABHD1 (abhydrolase domain containing 1) and ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Hydr1 in Genome Data Viewer
Location:
45A11-45A11; 2-60 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9132480..9135453)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5019985..5022958)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 2-10 Neighboring gene Glutathione S transferase E13 Neighboring gene uncharacterized protein Neighboring gene alicorn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shrub

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alpha/beta hydrolase2, a predicated gene adjacent to mad in Drosophila melanogaster, belongs to a new global multigene family and is associated with obesity. Wisotzkey RG, et al. J Mol Evol, 2003 Mar. PMID 12612838
  2. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article
  3. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Asha H, et al. Genetics, 2003 Jan. PMID 12586708, Free PMC Article
  4. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
  5. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables monoacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in medium-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
alpha/beta hydrolase 1
Names
CG8058-PA
CG8058-PB
CG8058-PC
CG8058-PD
CG8058-PE
Hydr1-PA
Hydr1-PB
Hydr1-PC
Hydr1-PD
Hydr1-PE
NP_001188892.1
NP_001286229.1
NP_001286230.1
NP_610459.2
NP_724757.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9132480..9135453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299300.1 → NP_001286229.1  alpha/beta hydrolase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286229.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCN3, Q95S61
    Conserved Domains (2) summary
    pfam00561
    Location:119 → 366
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:53 → 368
    Abhydrolase; alpha/beta hydrolases

  2. NM_001201963.2 → NP_001188892.1  alpha/beta hydrolase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188892.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Q7, Q95S61
    Conserved Domains (2) summary
    pfam00561
    Location:206 → 453
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:140 → 455
    Abhydrolase; alpha/beta hydrolases

  3. NM_165653.3 → NP_724757.2  alpha/beta hydrolase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724757.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCN3, Q95S61
    Conserved Domains (2) summary
    pfam00561
    Location:119 → 366
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:53 → 368
    Abhydrolase; alpha/beta hydrolases

  4. NM_136615.4 → NP_610459.2  alpha/beta hydrolase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610459.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Q7, Q95S61
    Related
    FBpp0087661
    Conserved Domains (2) summary
    pfam00561
    Location:206 → 453
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:140 → 455
    Abhydrolase; alpha/beta hydrolases

  5. NM_001299301.1 → NP_001286230.1  alpha/beta hydrolase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286230.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCN3, Q95S61
    Conserved Domains (2) summary
    pfam00561
    Location:119 → 366
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:53 → 368
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7Q7 A1Z7Q7
E2QCN3 E2QCN3
Q95S61 Q95S61

Gene LinkOut

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