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azot ahuizotl [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35751, updated on 18-Sep-2024

Summary

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Official Symbol
azotprovided by FlyBase
Official Full Name
ahuizotlprovided by FlyBase
Primary source
FLYBASE:FBgn0033238
Locus tag
Dmel_CG11165
See related
AllianceGenome:FB:FBgn0033238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Azot; BcDNA:AT10229; BcDNA:AT23738; CBP2; CG11165; Dmel\CG11165
Summary
Predicted to enable calcium ion binding activity and enzyme regulator activity. Involved in positive regulation of apoptotic process. Orthologous to human CALML5 (calmodulin like 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See azot in Genome Data Viewer
Location:
43F6-43F6; 2-57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7949839..7950465)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3837344..3837970)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Septin 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Azot expression in the Drosophila gut modulates organismal lifespan. Merino MM. Commun Integr Biol, 2023. PMID 36606245, Free PMC Article
  2. Cell Competition During Growth and Regeneration. Gogna R, et al. Annu Rev Genet, 2015. PMID 26631518
  3. Survival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer. Merino MM, et al. Trends Cell Biol, 2016 Oct. PMID 27319281
  4. Signaling interactions among neurons impact cell fitness and death in Alzheimer's disease. Yeates C, et al. Neural Regen Res, 2023 Apr. PMID 36204838, Free PMC Article
  5. Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline. Coelho DS, et al. Cell Rep, 2018 Dec 26. PMID 30590040, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ahuizotl
Names
CG11165-PA
azot-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7949839..7950465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136492.4 → NP_610336.1  ahuizotl [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610336.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q32KC3, Q7K049
    Related
    FBpp0087929
    Conserved Domains (2) summary
    PTZ00184
    Location:1 → 148
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:84 → 146
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K049 Q7K049
Q8IHA0 Q8IHA0

Gene LinkOut

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