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Br140 Bromodomain-containing protein, 140kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35648, updated on 2-Nov-2024

Summary

Official Symbol
Br140provided by FlyBase
Official Full Name
Bromodomain-containing protein, 140kDprovided by FlyBase
Primary source
FLYBASE:FBgn0033155
Locus tag
Dmel_CG1845
See related
AllianceGenome:FB:FBgn0033155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1845; Dmel\CG1845
Summary
Enables acetyltransferase activator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including embryonic anal pad; embryonic dorsal epidermis; embryonic ventral epidermis; lateral cord; and ventral midline of embryo. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to several human genes including BRPF1 (bromodomain and PHD finger containing 1) and BRPF3 (bromodomain and PHD finger containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Br140 in Genome Data Viewer
Location:
43A2-43A2; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7272275..7278101, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3159780..3165606, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45280 Neighboring gene uncharacterized protein Neighboring gene Inner centromere protein Neighboring gene pawn

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
Bromodomain-containing protein, 140kD
Names
Br140-PA
Br140-PB
CG1845-PA
CG1845-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7272275..7278101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299226.1NP_001286155.1  Bromodomain-containing protein, 140kD, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286155.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JVP4
    Conserved Domains (5) summary
    cd05839
    Location:13031414
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:615712
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15572
    Location:283336
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15670
    Location:340456
    ePHD_BRPF; Extended PHD finger found in BRPF proteins
    pfam10513
    Location:192264
    EPL1; Enhancer of polycomb-like
  2. NM_136422.3NP_610266.1  Bromodomain-containing protein, 140kD, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610266.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JVP4
    Related
    FBpp0088092
    Conserved Domains (5) summary
    cd05839
    Location:13031414
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:615712
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15572
    Location:283336
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15670
    Location:340456
    ePHD_BRPF; Extended PHD finger found in BRPF proteins
    pfam10513
    Location:192264
    EPL1; Enhancer of polycomb-like