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phtf phtf [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35583, updated on 2-Nov-2024

Summary

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Official Symbol
phtfprovided by FlyBase
Official Full Name
phtfprovided by FlyBase
Primary source
FLYBASE:FBgn0028579
Locus tag
Dmel_CG3268
See related
AllianceGenome:FB:FBgn0028579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA.GH08636; BcDNA:GH08636; CG3268; d-phtf; Dmel\CG3268
Summary
Predicted to enable channel activity. Predicted to be involved in transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval dorsal vessel; and male germline stem cell. Orthologous to human PHTF1 (putative homeodomain transcription factor 1) and PHTF2 (putative homeodomain transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See phtf in Genome Data Viewer
Location:
42C7-42C7; 2-55 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6741899..6746141)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2629404..2633646)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Zinc/iron regulated transporter-related protein 42C.2 Neighboring gene hulk Neighboring gene Methylcrotonoyl-CoA carboxylase 2 Neighboring gene Eb1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals. Manuel A, et al. Genomics, 2000 Mar 1. PMID 10729229
  2. Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins. Benton R, et al. Elife, 2023 Feb 20. PMID 36803935, Free PMC Article
  3. Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster. LaFerriere H, et al. Genetics, 2008 Apr. PMID 18430923, Free PMC Article
  4. The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. Devineni AV, et al. Fly (Austin), 2011 Jul-Sep. PMID 21750412, Free PMC Article
  5. Enhancer modeling uncovers transcriptional signatures of individual cardiac cell states in Drosophila. Busser BW, et al. Nucleic Acids Res, 2015 Feb 18. PMID 25609699, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables channel activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
phtf
Names
CG3268-PA
phtf-PA
putative homeodomain transcription factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6741899..6746141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136388.3 → NP_610232.1  phtf [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610232.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9TW25, Q9V9A8
    Related
    FBpp0085459
    Conserved Domains (1) summary
    pfam12129
    Location:3 → 184
    Phtf-FEM1B_bdg; Male germ-cell putative homeodomain transcription factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V9A8.2 Q9V9A8

Gene LinkOut

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