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Pld Phospholipase D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35554, updated on 2-Nov-2024

Summary

Official Symbol
Pldprovided by FlyBase
Official Full Name
Phospholipase Dprovided by FlyBase
Primary source
FLYBASE:FBgn0286511
Locus tag
Dmel_CG12110
See related
AllianceGenome:FB:FBgn0286511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12110; Dmel\CG12110; dPld; dPLD; MitoPLD; PC-Pld; phospholipase D; pld; PLD; pld1
Summary
Enables phospholipase D activity. Involved in several processes, including gastrulation involving germ band extension; phototransduction; and positive regulation of Golgi vesicle fusion to target membrane. Located in cytoplasmic vesicle. Is expressed in several structures, including adult head; embryonic anal pad; embryonic epipharynx; embryonic hypopharynx; and embryonic large intestine. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1) and PLD2 (phospholipase D2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Pld in Genome Data Viewer
Location:
42A14-42A14; 2-55 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6242004..6255266)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2129509..2142771)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44161 Neighboring gene tomboy40 Neighboring gene bicoid-interacting protein 3 Neighboring gene long non-coding RNA:CR46075 Neighboring gene long non-coding RNA:CR45127 Neighboring gene jing

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

mobile_element

  • Loc: 6243270-6243442 mobile_element_type = transposon:INE-1{}1750

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase D activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipase D activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellularization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gastrulation involving germ band extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Golgi vesicle fusion to target membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phospholipase D
Names
CG12110-PA
CG12110-PB
CG12110-PC
CG12110-PD
CG12110-PF
CG12110-PG
Phosphatidylcholine-specific phospholipase-D
Pld-PA
Pld-PB
Pld-PC
Pld-PD
Pld-PF
Pld-PG
NP_001137610.1
NP_523627.3
NP_724469.2
NP_724470.2
NP_724471.2
NP_724472.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6242004..6255266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165470.3NP_724470.2  phospholipase D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724470.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KML4, Q9BP35
    Conserved Domains (4) summary
    cd06895
    Location:144345
    PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
    cd09138
    Location:504648
    PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd09141
    Location:9461134
    PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd01254
    Location:333478
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
  2. NM_165469.4NP_724469.2  phospholipase D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724469.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KML4, Q9BP35
    Conserved Domains (4) summary
    cd06895
    Location:144345
    PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
    cd09138
    Location:504648
    PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd09141
    Location:9461134
    PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd01254
    Location:333478
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
  3. NM_165471.3NP_724471.2  phospholipase D, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724471.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KML4, Q9BP35
    Conserved Domains (4) summary
    cd06895
    Location:144345
    PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
    cd09138
    Location:504648
    PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd09141
    Location:9461134
    PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd01254
    Location:333478
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
  4. NM_001144138.2NP_001137610.1  phospholipase D, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137610.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZT5, Q9BP35
    Conserved Domains (4) summary
    cd06895
    Location:230431
    PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
    cd09138
    Location:590734
    PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd09141
    Location:10321220
    PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd01254
    Location:419564
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
  5. NM_078903.4NP_523627.3  phospholipase D, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523627.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KML4, Q9BP35
    Conserved Domains (4) summary
    cd06895
    Location:144345
    PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
    cd09138
    Location:504648
    PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd09141
    Location:9461134
    PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd01254
    Location:333478
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
  6. NM_165472.3NP_724472.3  phospholipase D, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724472.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZ54, Q9BP35
    Conserved Domains (5) summary
    cd06895
    Location:144338
    PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
    cd09138
    Location:486630
    PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd09141
    Location:9281116
    PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    PLN02866
    Location:3661245
    PLN02866; phospholipase D
    cd01254
    Location:339460
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain