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Mondo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35402, updated on 4-Jul-2024

Summary

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Official Symbol
Mondoprovided by FlyBase
Primary source
FLYBASE:FBgn0032940
Locus tag
Dmel_CG18362
See related
AllianceGenome:FB:FBgn0032940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
154826_at; anon-39Da; bHLHd12; CG18362; ChREBP; Dmel\CG18362; dmondo; mio; Mio; mlx; mondo; Mondo-Mlx
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Predicted to contribute to DNA binding activity. Involved in glucose homeostasis; response to sucrose; and triglyceride homeostasis. Located in cytosol. Is expressed in several structures, including blastoderm embryo; brain; embryonic/larval fat body; extended germ band embryo; and germ layer. Orthologous to human MLXIP (MLX interacting protein) and MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Mondo in Genome Data Viewer
Location:
39C1-39C2; 2-54 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21286078..21310050, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21286078..21310050, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mir-4974 stem loop Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Gustatory receptor 39a Neighboring gene long non-coding RNA:CR44785 Neighboring gene cryptocephal Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Regulation of Muscle Structure and Metabolism by Mio/dChREBP in Drosophila. Polak GL, et al. PLoS One, 2015. PMID 26305467, Free PMC Article
  2. Mio acts in the Drosophila brain to control nutrient storage and feeding. Docherty JE, et al. Gene, 2015 Sep 1. PMID 26024590, Free PMC Article
  3. A novel N-terminal domain may dictate the glucose response of Mondo proteins. McFerrin LG, et al. PLoS One, 2012. PMID 22506051, Free PMC Article
  4. Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. Musselman LP, et al. J Biol Chem, 2013 Mar 22. PMID 23355467, Free PMC Article
  5. Sugar sensing by ChREBP/Mondo-Mlx-new insight into downstream regulatory networks and integration of nutrient-derived signals. Havula E, et al. Curr Opin Cell Biol, 2018 Apr. PMID 29278834

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mondo-Mlx maintains metabolic homeostasis through Activin ligand Dawdle and the Gli-similar transcription factor Sugarbabe.
    Title: Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe.
  2. these data indicate a novel role for Mio in controlling muscle structure and metabolism and may provide a molecular link between nutrient availability and muscle function.
    Title: The Regulation of Muscle Structure and Metabolism by Mio/dChREBP in Drosophila.
  3. A new function for Mio in the Drosophila brain and specifically in the insulin producing cells.
    Title: Mio acts in the Drosophila brain to control nutrient storage and feeding.
  4. these data implicate a role for Mio in controlling fat accumulation in Drosophila and suggests that it may act as a nutrient sensor in the fat body to coordinate feeding behavior with nutrient availability.
    Title: Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c21289960-21289891 mobile_element_type = transposon:INE-1{}5444
  • Loc: c21290304-21290216 mobile_element_type = transposon:INE-1{}5445
  • Loc: c21296051-21295962 mobile_element_type = transposon:INE-1{}4059
  • Loc: c21302595-21302038 mobile_element_type = transposon:INE-1{}5450
  • Loc: c21307362-21306708 mobile_element_type = transposon:INE-1{}4065

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to sucrose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
mondo
Names
CG18362-PA
CG18362-PB
CG18362-PE
CG18362-PF
CG18362-PG
CG18362-PH
CG18362-PI
CG18362-PJ
CG18362-PK
CG18362-PL
CG18362-PM
Mlx interactor
Mondo-PA
Mondo-PB
Mondo-PE
Mondo-PF
Mondo-PG
Mondo-PH
Mondo-PI
Mondo-PJ
Mondo-PK
Mondo-PL
Mondo-PM
WBSCR14-related

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21286078..21310050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169567.2 → NP_001163038.1  mondo, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163038.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  2. NM_001169562.2 → NP_001163033.1  mondo, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163033.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  3. NM_001169566.2 → NP_001163037.1  mondo, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163037.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  4. NM_165367.2 → NP_724326.1  mondo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724326.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Related
    FBpp0081053
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  5. NM_001169568.2 → NP_001163039.1  mondo, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163039.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  6. NM_136261.3 → NP_610105.2  mondo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610105.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Related
    FBpp0081052
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  7. NM_001169564.2 → NP_001163035.1  mondo, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163035.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  8. NM_001169563.2 → NP_001163034.1  mondo, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163034.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  9. NM_001169565.2 → NP_001163036.1  mondo, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163036.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  10. NM_165368.1 → NP_724327.1  mondo, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724327.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAC9, Q8INT6
    Related
    FBpp0081055, FBtr0081527
    Conserved Domains (1) summary
    cd00083
    Location:715 → 775
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  11. NM_001169561.2 → NP_001163032.1  mondo, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163032.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960S1, Q9BKE5, Q9BKE6, Q9VID4
    Conserved Domains (1) summary
    cd00083
    Location:909 → 969
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8INT6 Q8INT6
Q9BKE4 Q9BKE4
Q9BKE5 Q9BKE5
Q9VID4 Q9VID4

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