szl sizzled [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: szlprovided by ZNC
Official Full Name: sizzledprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030530-1
See related: Ensembl:ENSDARG00000099637 AllianceGenome:ZFIN:ZDB-GENE-030530-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: slz; sfrp
Summary: Predicted to enable Wnt-protein binding activity. Acts upstream of or within several processes, including determination of dorsal identity; negative regulation of BMP signaling pathway; and protein stabilization. Predicted to be active in extracellular space. Is expressed in ectoderm; mesoderm; periderm; and tail bud. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (371412..375892, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (348505..352985, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of szl, a secreted frizzled-related protein.
Title: The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of dorsal identity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein stabilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sizzled

Names: mercedes; mes; ogo; ogon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181663.1 → NP_858049.1 sizzled precursor

See identical proteins and their annotated locations for NP_858049.1

Status: PROVISIONAL

Source sequence(s)

AB093587

UniProtKB/TrEMBL

Q1JPW5, Q7SX78

Related

ENSDARP00000133257.1, ENSDART00000165705.3

Conserved Domains (2) summary

cd03580
Location:152 → 282

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

cl02447
Location:19 → 158

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain