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Sgms1 sphingomyelin synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 353229, updated on 10-Oct-2024

Summary

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Official Symbol
Sgms1provided by RGD
Official Full Name
sphingomyelin synthase 1provided by RGD
Primary source
RGD:727912
See related
EnsemblRapid:ENSRNOG00000012536 AllianceGenome:RGD:727912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mob; mob-1; Tmem23
Summary
Predicted to enable ceramide cholinephosphotransferase activity; ceramide phosphoethanolamine synthase activity; and sphingomyelin synthase activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; and inflammatory response. Predicted to be located in Golgi trans cisterna. Predicted to be integral component of Golgi membrane; integral component of endoplasmic reticulum membrane; and integral component of plasma membrane. Used to study pulmonary edema. Biomarker of pulmonary edema. Orthologous to human SGMS1 (sphingomyelin synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 378.2), Kidney (RPKM 279.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sgms1 in Genome Data Viewer
Location:
1q52
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239409991..239681195, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (229996673..230259591, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (250692448..250951685, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene APOBEC1 complementation factor Neighboring gene N-acylsphingosine amidohydrolase 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene nuclear transport factor 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Developmental stage-specific expression of genes for sphingomyelin synthase in rat brain. Filippenkov IB, et al. Cell Tissue Res, 2018 Apr. PMID 29294205
  2. The mouse sphingomyelin synthase 1 (SMS1) gene is alternatively spliced to yield multiple transcripts and proteins. Yang Z, et al. Gene, 2005 Dec 19. PMID 16226406
  3. MOB-1 and TNF-alpha interact to induce microvascular lung injury. Rabinovici R, et al. Shock, 2002 Sep. PMID 12353928
  4. Circular RNA of the human sphingomyelin synthase 1 gene: Multiple splice variants, evolutionary conservatism and expression in different tissues. Filippenkov IB, et al. RNA Biol, 2015. PMID 26274505, Free PMC Article
  5. Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells. Yamaoka S, et al. J Biol Chem, 2004 Apr 30. PMID 14976195

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in contrast to Sgms1, Sgms2 does not contain the multi-exon 5'-UTR but encodes circRNAs, which are composed of the coding region of the gene and are expressed at a low level.
    Title: Developmental stage-specific expression of genes for sphingomyelin synthase in rat brain.
  2. SMS1 and SMS2 are capable of regulating TGN-mediated protein trafficking and secretion
    Title: Sphingomyelin synthases regulate protein trafficking and secretion.
  3. mob-1 and TNF-alpha interact to promote lung inflammation
    Title: MOB-1 and TNF-alpha interact to induce microvascular lung injury.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93062

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ceramide cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide cholinephosphotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ceramide cholinephosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ceramide phosphoethanolamine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingomyelin synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables sphingomyelin synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sphingomyelin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingomyelin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingomyelin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi trans cisterna ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylcholine:ceramide cholinephosphotransferase 1
Names
protein Mob
transmembrane protein 23
NP_852051.2
XP_038936909.1
XP_038936911.1
XP_038936916.1
XP_038936922.1
XP_038936925.1
XP_038936926.1
XP_038936929.1
XP_038936937.1
XP_038936942.1
XP_038936946.1
XP_063121795.1
XP_063121800.1
XP_063121802.1
XP_063121807.1
XP_063121810.1
XP_063121813.1
XP_063121819.1
XP_063121824.1
XP_063121829.1
XP_063121834.1
XP_063121837.1
XP_063121840.1
XP_063121846.1
XP_063121847.1
XP_063121851.1
XP_063121856.1
XP_063121860.1
XP_063121863.1
XP_063121867.1
XP_063121876.1
XP_063121886.1
XP_063121889.1
XP_063121892.1
XP_063121893.1
XP_063121901.1
XP_063121906.1
XP_063121908.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181386.3 → NP_852051.2  phosphatidylcholine:ceramide cholinephosphotransferase 1

    See identical proteins and their annotated locations for NP_852051.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104
    Conserved Domains (2) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    239409991..239681195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265797.1 → XP_063121867.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  2. XM_063265725.1 → XP_063121795.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  3. XM_063265790.1 → XP_063121860.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  4. XM_063265754.1 → XP_063121824.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  5. XM_063265770.1 → XP_063121840.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  6. XM_063265743.1 → XP_063121813.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  7. XM_039080997.2 → XP_038936925.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104
    Conserved Domains (2) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

  8. XM_039080981.2 → XP_038936909.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104
    Conserved Domains (2) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

  9. XM_063265737.1 → XP_063121807.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  10. XM_039080994.2 → XP_038936922.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104
    Conserved Domains (2) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

  11. XM_063265730.1 → XP_063121800.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  12. XM_063265732.1 → XP_063121802.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  13. XM_063265759.1 → XP_063121829.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  14. XM_063265767.1 → XP_063121837.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  15. XM_063265793.1 → XP_063121863.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  16. XM_063265764.1 → XP_063121834.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  17. XM_039080983.2 → XP_038936911.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104
    Conserved Domains (2) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

  18. XM_039080988.2 → XP_038936916.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104
    Conserved Domains (2) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

  19. XM_063265781.1 → XP_063121851.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  20. XM_063265776.1 → XP_063121846.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  21. XM_063265777.1 → XP_063121847.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  22. XM_063265740.1 → XP_063121810.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  23. XM_063265786.1 → XP_063121856.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  24. XM_063265749.1 → XP_063121819.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104

  25. XM_039080998.2 → XP_038936926.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104
    Conserved Domains (2) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

  26. XM_039081001.2 → XP_038936929.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104
    Related
    ENSRNOP00000051643.1, ENSRNOT00000054761.3
    Conserved Domains (2) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

  27. XM_039081009.2 → XP_038936937.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSX5
    UniProtKB/TrEMBL
    A6I104
    Conserved Domains (2) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

  28. XM_063265806.1 → XP_063121876.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X2

  29. XM_063265838.1 → XP_063121908.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X4

  30. XM_063265836.1 → XP_063121906.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X4

  31. XM_063265822.1 → XP_063121892.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

  32. XM_063265816.1 → XP_063121886.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

  33. XM_039081014.2 → XP_038936942.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JYM5, A6I105
    Conserved Domains (1) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase

  34. XM_063265819.1 → XP_063121889.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

  35. XM_063265823.1 → XP_063121893.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

  36. XM_063265831.1 → XP_063121901.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X3

  37. XM_039081018.2 → XP_038936946.1  phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JYM5, A6I105
    Conserved Domains (1) summary
    cd09514
    Location:7 → 78
    SAM_SGMS1; SAM domain of sphingomyelin synthase

RNA

  1. XR_005487755.2 RNA Sequence

  2. XR_010053998.1 RNA Sequence

  3. XR_010054000.1 RNA Sequence

  4. XR_010053999.1 RNA Sequence

  5. XR_010054001.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSX5.2 GenPept UniProtKB/Swiss-Prot:Q7TSX5

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