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CG10602 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35146, updated on 18-Sep-2024

Summary

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Official Symbol
CG10602provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032721
Locus tag
Dmel_CG10602
See related
AllianceGenome:FB:FBgn0032721
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10602; pepCG10602
Summary
Predicted to enable aminopeptidase activity and epoxide hydrolase activity. Predicted to be involved in peptide catabolic process. Predicted to be located in ribosome. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval crystal cell; mesoderm; and procrystal cell. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG10602 in Genome Data Viewer
Location:
37B1-37B1; 2-54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18855126..18859248, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18855126..18859248, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene tailup Neighboring gene mir-4946 stem loop Neighboring gene long non-coding RNA:CR44737

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation. Villegas SN, et al. Cell Rep, 2018 Mar 6. PMID 29514083
  2. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article
  3. A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster. Scarpati M, et al. PLoS One, 2019. PMID 30753230, Free PMC Article
  4. Targets of microRNA regulation in the Drosophila oocyte proteome. Nakahara K, et al. Proc Natl Acad Sci U S A, 2005 Aug 23. PMID 16099838, Free PMC Article
  5. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables epoxide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10602-PC
CG10602-PD
CG10602-PF
NP_609916.5
NP_724139.1
NP_724140.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18855126..18859248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136072.5 → NP_609916.5  uncharacterized protein Dmel_CG10602, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KT44, Q961A0, Q9VJ39, R4GRV7
    Conserved Domains (4) summary
    cd09599
    Location:79 → 520
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    TIGR02411
    Location:79 → 681
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    pfam09127
    Location:541 → 680
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl00333
    Location:16 → 50
    Ribosomal_L13; Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the ...

  2. NM_165268.3 → NP_724139.1  uncharacterized protein Dmel_CG10602, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724139.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V0U4
    Related
    FBpp0088357
    Conserved Domains (3) summary
    cd09599
    Location:8 → 449
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    TIGR02411
    Location:8 → 610
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    pfam09127
    Location:470 → 609
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

  3. NM_165269.3 → NP_724140.1  uncharacterized protein Dmel_CG10602, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724140.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V0U4
    Related
    FBpp0088356
    Conserved Domains (3) summary
    cd09599
    Location:8 → 449
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    TIGR02411
    Location:8 → 610
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    pfam09127
    Location:470 → 609
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V0U4 A4V0U4
Q9VJ39 Q9VJ39

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