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Cyt-b5-r Cytochrome b5-related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35008, updated on 2-Nov-2024

Summary

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Official Symbol
Cyt-b5-rprovided by FlyBase
Official Full Name
Cytochrome b5-relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0000406
Locus tag
Dmel_CG13279
See related
AllianceGenome:FB:FBgn0000406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13279; Cyt-b; Cyt-b5; Cytb; Cytb5; Cytb5r; Dmel\CG13279; TU-36B; TU36B
Summary
Predicted to enable heme binding activity and oxidoreductase activity. Predicted to be involved in lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval crystal cell; and muscle cell. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Cyt-b5-r in Genome Data Viewer
Location:
36B1-36B1; 2-53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16788774..16790721, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16788774..16790721, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene yellow-b Neighboring gene pickpocket 17 Neighboring gene Myosin heavy chain Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 37 member C2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and expression of a muscle specific gene which is adjacent to the Drosophila myosin heavy-chain gene and can encode a cytochrome b related protein. Levin RJ, et al. Nucleic Acids Res, 1989 Aug 11. PMID 2549511, Free PMC Article
  2. Expression and translocation of Drosophila nuclear encoded cytochrome b(5) proteins to mitochondria. Kula ME, et al. Insect Biochem Mol Biol, 2000 Oct. PMID 10899459
  3. Biochemical membrane lipidomics during Drosophila development. Guan XL, et al. Dev Cell, 2013 Jan 14. PMID 23260625
  4. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Lemos B, et al. Science, 2008 Jan 4. PMID 18174442
  5. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. Zhao X, et al. J Clin Invest, 2012 Jul. PMID 22684109, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytochrome b5-related
Names
CG13279-PA
CG13279-PB
Cyt-b5-r-PA
Cyt-b5-r-PB
NP_001260514.1
NP_477154.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16788774..16790721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273585.1 → NP_001260514.1  cytochrome b5-related, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260514.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19967, Q9VJI2
    UniProtKB/TrEMBL
    M9PD26
    Conserved Domains (3) summary
    pfam00173
    Location:26 → 98
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam00487
    Location:161 → 408
    FA_desaturase; Fatty acid desaturase
    cl00615
    Location:328 → 385
    Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...

  2. NM_057806.5 → NP_477154.1  cytochrome b5-related, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477154.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19967, Q9VJI2
    UniProtKB/TrEMBL
    M9PD26
    Related
    FBpp0080486
    Conserved Domains (3) summary
    pfam00173
    Location:26 → 98
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    pfam00487
    Location:161 → 408
    FA_desaturase; Fatty acid desaturase
    cl00615
    Location:328 → 385
    Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PD26 M9PD26
P19967.2 P19967

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