wor worniu [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: worprovided by FlyBase
Official Full Name: worniuprovided by FlyBase
Primary source: FLYBASE:FBgn0001983
Locus tag: Dmel_CG4158
See related: AllianceGenome:FB:FBgn0001983
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS03023.1; br35; CG4158; Dmel\CG4158; l(2)35Da; l(2)br35; l35Da; Wor
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in nervous system development; positive regulation of transcription by RNA polymerase II; and regulation of neural precursor cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; neuroblasts; presumptive embryonic/larval central nervous system; and procephalic neurogenic region. Used to study central nervous system cancer. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 2D and piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 35D2-35D2; 2-51 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15423297..15425580, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15423297..15425580, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.
Title: Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.
The Worniu is continuously required in neuroblasts to maintain self-renewal by promoting cell-cycle progression and inhibiting premature differentiation.
Title: The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation.
snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu.
Title: The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu.
Results suggest that the loss of Worniu function within the neuroblasts ultimately causes the larval brainstem to fail to go through shortening during development.
Title: Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neural precursor cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: worniu

Names: CG4158-PA; D.m.Worniu; lethal(2)35Da; schnecke; warniu; wor-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

15423297..15425580 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057253.4 → NP_476601.1 worniu [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476601.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SXL3, Q9U7P8, Q9VJP2

Related

FBpp0080299

Conserved Domains (5) summary

PHA00732
Location:379 → 417

PHA00732; hypothetical protein

sd00017
Location:408 → 428

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:434 → 456

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:421 → 444

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:405 → 482

zf-C2H2_8; C2H2-type zinc ribbon