vas vasa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Gene symbol: vas
Gene description: vasa
Locus tag: Dmel_CG43081
See related: FLYBASE:FBgn0262526
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS00929.14; BG:DS00929.15; CG33678; CG3506; CG43081; cgt; Dmel\CG43081; DmRH25; EP(2)0812; fs(2)ltoRJ36; pf7; solo; Vas; VAS; Vasa; VASA
Old locus tag: Dmel_CG33678; Dmel_CG3506
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Genomic context

Location:: 35C1-35C1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 5.57	latest, but not current	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15061656..15074383)

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NT_033779.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We propose that SOLO is a subunit of a specialized meiotic cohesin complex that mediates both centromeric and axial arm cohesion and promotes homolog bias as a component of chromosome cores.
Title: The cohesion protein SOLO associates with SMC1 and is required for synapsis, recombination, homolog bias and cohesion and pairing of centromeres in Drosophila Meiosis.
Study presents evidence that UAP56 and Vas are cluster transcript binding proteins that organize a piRNA-processing compartment that spans the nuclear envelope.
Title: UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery.
Oskar recruits two downstream components of the polar granules, Vasa and Tudor, independently from each other: Vasa directly interacts with Oskar while Valois mediates the recruitment of Tudor by interacting with Oskar and Tudor
Title: Targeting and anchoring Tudor in the pole plasm of the Drosophila oocyte.
These results suggest that Vas functions during mitosis and may link the piRNA pathway to mitotic chromosome condensation in Drosophila.
Title: A role for vasa in regulating mitotic chromosome condensation in Drosophila.
The RNA helicase Vasa is another essential protein in germline development and arginine methylation is conserved across phyla
Title: Arginine methylation of vasa protein is conserved across phyla.
Data suggest that Fsn- and Gus-containing E3 ligase complexes contribute to establishing a fine-tuned steady state of Vasa ubiquitination that influences the kinetics of posterior Vasa deployment.
Title: Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors.
Vas promotes germ cell differentiation by directly activating mei-P26 translation in early-stage committed cells
Title: Vasa promotes Drosophila germline stem cell differentiation by activating mei-P26 translation by directly interacting with a (U)-rich motif in its 3' UTR.
VASA and AUBERGINE proteins are known as components of perinuclear ribonucleoprotein particles in germ cells that participate in the same silencing pathway, and spn-E mutation disturbs protein content of the particle
Title: The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster.
Identification of a transcriptional regulatory region for germline-specific expression of vasa gene in Drosophila melanogaster
Title: Identification of a transcriptional regulatory region for germline-specific expression of vasa gene in Drosophila melanogaster.
The vlsnull mutant shows that Valois+ is required for normal posterior localization of Oskar in later stages of oogenesis and for posterior localization of the Vasa protein during the entire process of pole plasm assembly
Title: Drosophila valois encodes a divergent WD protein that is required for Vasa localization and Oskar protein accumulation.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General protein information

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Preferred Names: CG43081 gene product from transcript CG43081-RC

Names: CG43081-PA; CG43081-PB; CG43081-PC; VASA; Vas; courgette; female sterile(2)ltoRJ36; no-relish; sisters on the loose; vas-PA; vas-PB; vas-PC; vasa