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hll heimdall [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34822, updated on 18-Sep-2024

Summary

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Official Symbol
hllprovided by FlyBase
Official Full Name
heimdallprovided by FlyBase
Primary source
FLYBASE:FBgn0286723
Locus tag
Dmel_CG4500
See related
AllianceGenome:FB:FBgn0286723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2a9; anon-EST:CL2a9; BG:DS05899.1; bgm-l; CG4500; dbb; Dmel\CG4500; I
Summary
Enables long-chain fatty acid-CoA ligase activity. Involved in several processes, including neuron cellular homeostasis; positive regulation of circadian sleep/wake cycle, sleep; and triglyceride homeostasis. Is expressed in several structures, including embryonic/larval fat body; gastrula embryo; mesoderm anlage; and yolk. Used to study adrenoleukodystrophy. Orthologous to human ACSBG2 (acyl-CoA synthetase bubblegum family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See hll in Genome Data Viewer
Location:
34F1-34F1; 2-50 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14027001..14029368)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14027001..14029368)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45352 Neighboring gene long non-coding RNA:CR31840 Neighboring gene long non-coding RNA:CR45284 Neighboring gene uncharacterized protein Neighboring gene nicotinic Acetylcholine Receptor alpha5 Neighboring gene Nimrod C4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases. Sivachenko A, et al. Dis Model Mech, 2016 Apr. PMID 26893370, Free PMC Article
  2. The acyl-CoA Synthetase, pudgy, Promotes Sleep and Is Required for the Homeostatic Response to Sleep Deprivation. Thimgan MS, et al. Front Endocrinol (Lausanne), 2018. PMID 30186232, Free PMC Article
  3. DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons. Nitta Y, et al. Dev Biol, 2017 Jan 15. PMID 27908785
  4. Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila. Gordon HB, et al. Dis Model Mech, 2018 Jun 15. PMID 29739804, Free PMC Article
  5. The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption. Riahi H, et al. PLoS Biol, 2019 Mar. PMID 30860988, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fatty acid ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heimdall
Names
CG4500-PA
bubblegum-like
double bubble
doublebubble
hll-PA
NP_609696.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14027001..14029368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135852.4 → NP_609696.1  heimdall [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609696.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SWR5, Q9V3U0
    Related
    FBpp0080168
    Conserved Domains (1) summary
    cl17068
    Location:62 → 680
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3U0.1 Q9V3U0

Gene LinkOut

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