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Rsph1 Radial spoke head protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34712, updated on 18-Sep-2024

Summary

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Official Symbol
Rsph1provided by FlyBase
Official Full Name
Radial spoke head protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0032478
Locus tag
Dmel_CG5458
See related
AllianceGenome:FB:FBgn0032478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5458; Dmel\CG5458; dRSPH1
Summary
Involved in axoneme assembly. Predicted to be located in cytosol and nucleus. Is expressed in adult head; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 24. Orthologous to human RSPH1 (radial spoke head component 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Rsph1 in Genome Data Viewer
Location:
34A8-34A8; 2-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13183450..13184875)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13183450..13184875)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Neighboring gene uncharacterized protein Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene uncharacterized protein Neighboring gene Phosphoethanolamine cytidylyltransferase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila. Wang Y, et al. J Genet Genomics, 2019 Jun 20. PMID 31281031
  2. Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors. Blümel L, et al. Cell Death Dis, 2022 Sep 20. PMID 36127323, Free PMC Article
  3. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article
  4. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
  5. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Bellen HJ, et al. Genetics, 2004 Jun. PMID 15238527, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axoneme assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
radial spoke head protein 1
Names
CG5458-PA
Rsph1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13183450..13184875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135765.4 → NP_609609.1  radial spoke head protein 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609609.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VK29
    Related
    FBpp0080018
    Conserved Domains (2) summary
    smart00698
    Location:95 → 116
    MORN; Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
    pfam02493
    Location:51 → 73
    MORN; MORN repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VK29 Q9VK29

Gene LinkOut

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