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Phae1 Phaedra 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34637, updated on 18-Sep-2024

Summary

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Official Symbol
Phae1provided by FlyBase
Official Full Name
Phaedra 1provided by FlyBase
Primary source
FLYBASE:FBgn0263234
Locus tag
Dmel_CG16996
See related
AllianceGenome:FB:FBgn0263234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16996; Dmel\CG16996; SP134
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Phae1 in Genome Data Viewer
Location:
33C4-33C4; 2-46 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12109417..12110664)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12109417..12110664)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Threonyl-tRNA synthetase Neighboring gene Rab6 Neighboring gene Phaedra 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The developmental role of warthog, the notch modifier encoding Drab6. Purcell K, et al. J Cell Biol, 1999 Aug 23. PMID 10459009, Free PMC Article
  2. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Jiao J, et al. Cell Rep, 2023 Jan 31. PMID 36640359, Free PMC Article
  3. Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Kumar S, et al. Sci Rep, 2016 Nov 7. PMID 27819340, Free PMC Article
  4. The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). Carpenter J, et al. PLoS One, 2009 Aug 31. PMID 19718442, Free PMC Article
  5. Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. McGraw LA, et al. Curr Biol, 2004 Aug 24. PMID 15324670

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
phaedra 1
Names
CG16996-PA
CG16996-PB
Phae1-PA
Phae1-PB
NP_001285870.1
NP_609550.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12109417..12110664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298941.1 → NP_001285870.1  phaedra 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285870.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKA9
    Conserved Domains (2) summary
    smart00020
    Location:35 → 263
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:36 → 266
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_135706.4 → NP_609550.1  phaedra 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609550.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKA9
    Related
    FBpp0079916
    Conserved Domains (2) summary
    smart00020
    Location:35 → 263
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:36 → 266
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKA9 Q9VKA9

Gene LinkOut

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