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YL-1 YL-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34516, updated on 18-Sep-2024

Summary

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Official Symbol
YL-1provided by FlyBase
Official Full Name
YL-1provided by FlyBase
Primary source
FLYBASE:FBgn0032321
Locus tag
Dmel_CG4621
See related
AllianceGenome:FB:FBgn0032321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4621; Dmel\CG4621; dYL-1; dYL1; YL1
Summary
Involved in histone acetylation; histone exchange; and negative regulation of gene expression. Located in nucleus. Part of NuA4 histone acetyltransferase complex. Is expressed in organism. Orthologous to human VPS72 (vacuolar protein sorting 72 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See YL-1 in Genome Data Viewer
Location:
32C1-32C1; 2-44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10970443..10972093)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10970443..10972093)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 2 Neighboring gene long non-coding RNA:CR44493 Neighboring gene Transmembrane protein 214 Neighboring gene uncharacterized protein Neighboring gene abnormal oocyte

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. Liang X, et al. Nat Struct Mol Biol, 2016 Apr. PMID 26974124
  2. Nucleosomes are context-specific, H2A.Z-modulated barriers to RNA polymerase. Weber CM, et al. Mol Cell, 2014 Mar 6. PMID 24606920
  3. In Vivo Silencing of Genes Coding for dTip60 Chromatin Remodeling Complex Subunits Affects Polytene Chromosome Organization and Proper Development in Drosophila melanogaster. Prozzillo Y, et al. Int J Mol Sci, 2021 Apr 26. PMID 33926075, Free PMC Article
  4. Genetic variants regulating expression levels and isoform diversity during embryogenesis. Cannavò E, et al. Nature, 2017 Jan 19. PMID 28024300
  5. In and out: histone variant exchange in chromatin. Jin J, et al. Trends Biochem Sci, 2005 Dec. PMID 16257529

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
YL-1
Names
CG4621-PA
CG4621-PB
YL-1-PA
YL-1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10970443..10972093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298894.1 → NP_001285823.1  YL-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285823.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VKM6
    UniProtKB/TrEMBL
    X2JA36
    Conserved Domains (3) summary
    smart00993
    Location:276 → 304
    YL1_C; YL1 nuclear protein C-terminal domain
    pfam04180
    Location:20 → 75
    LTV; Low temperature viability protein
    pfam05764
    Location:3 → 218
    YL1; YL1 nuclear protein

  2. NM_135631.4 → NP_609475.1  YL-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609475.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VKM6
    UniProtKB/TrEMBL
    X2JA36
    Related
    FBpp0079735
    Conserved Domains (3) summary
    smart00993
    Location:276 → 304
    YL1_C; YL1 nuclear protein C-terminal domain
    pfam04180
    Location:20 → 75
    LTV; Low temperature viability protein
    pfam05764
    Location:3 → 218
    YL1; YL1 nuclear protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKM6.1 Q9VKM6
X2JA36 X2JA36

Gene LinkOut

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