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PAQR9 progestin and adipoQ receptor family member 9 [ Homo sapiens (human) ]

Gene ID: 344838, updated on 2-Nov-2024

Summary

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Official Symbol
PAQR9provided by HGNC
Official Full Name
progestin and adipoQ receptor family member 9provided by HGNC
Primary source
HGNC:HGNC:30131
See related
Ensembl:ENSG00000188582 MIM:614580; AllianceGenome:HGNC:30131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLNC1
Summary
Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See PAQR9 in Genome Data Viewer
Location:
3q23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (142949164..142964008, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (145696407..145711250, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142668006..142682850, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene uncharacterized LOC124909443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14791 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:142635932-142636110 Neighboring gene Sharpr-MPRA regulatory region 3462 Neighboring gene hepatic lncRNA metabolic regulator 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:142677150-142678349 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:142681545-142681730 Neighboring gene PAQR9 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:142717850-142718850 Neighboring gene uncharacterized LOC100289361 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:142719850-142720849 Neighboring gene U2 snRNP associated SURP domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subcellular distribution of glutamyltransferase activities in embryonic cerebral hemispheres. Piddington R. Brain Res, 1977 Jun 17. PMID 18257
  2. Synaptosome transmitter release and ATPase activity [proceedings]. Gilbert JC, et al. Br J Pharmacol, 1977 Jun. PMID 18252, Free PMC Article
  3. Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis. Pang Y, et al. Endocrinology, 2013 Jan. PMID 23161870, Free PMC Article
  4. PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα. Lin Y, et al. Mol Metab, 2021 Nov. PMID 34474167, Free PMC Article
  5. Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors. Smith JL, et al. Steroids, 2008 Oct. PMID 18603275, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARalpha.
    Title: PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα.
  2. the polyubiquitination of MLPs is enhanced by PAQR9 PAQR9 binds to the DUF3538 domain within the proline-rich stretch of BAG6. PAQR9 reduces the binding of MLPs to BAG6 in a DUF3538 domain-dependent manner. Taken together, our results indicate that PAQR9 plays a role in the regulation of protein quality control of MLPs via affecting the interaction of BAG6 with membrane proteins.
    Title: PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins.
  3. The results suggest that PAQR6 and PAQR9 (mPRdelta and mPRepsilon) function as mPRs coupled to G proteins and are potential intermediaries of nonclassical antiapoptotic actions of neurosteroids in the central nervous system.
    Title: Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis.
  4. PAQR9 is a previously uncharacterized PAQR which is also capable of responding to progesterone.
    Title: Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41938

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane progestin receptor epsilon
Names
brown fat long noncoding RNA
mPR epsilon
membrane progesterone P4 receptor epsilon
membrane progesterone receptor epsilon
progesterone and adipoQ receptor family member 9
progestin and adipoQ receptor family member IX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375300.1 → NP_001362229.1  membrane progestin receptor epsilon isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC021074
    Conserved Domains (1) summary
    cl03831
    Location:81 → 320
    HlyIII; Haemolysin-III related

  2. NM_001375301.1 → NP_001362230.1  membrane progestin receptor epsilon isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC021074
    Conserved Domains (1) summary
    cl03831
    Location:81 → 320
    HlyIII; Haemolysin-III related

  3. NM_198504.4 → NP_940906.1  membrane progestin receptor epsilon isoform 1

    See identical proteins and their annotated locations for NP_940906.1

    Status: VALIDATED

    Source sequence(s)
    AC021074
    Consensus CDS
    CCDS3128.1
    UniProtKB/Swiss-Prot
    Q147T6, Q6ZVX9
    Related
    ENSP00000341564.4, ENST00000340634.6
    Conserved Domains (1) summary
    cl03831
    Location:81 → 320
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    142949164..142964008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    145696407..145711250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZVX9.1 GenPept UniProtKB/Swiss-Prot:Q6ZVX9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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