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LRRIQ4 leucine rich repeats and IQ motif containing 4 [ Homo sapiens (human) ]

Gene ID: 344657, updated on 2-Nov-2024

Summary

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Official Symbol
LRRIQ4provided by HGNC
Official Full Name
leucine rich repeats and IQ motif containing 4provided by HGNC
Primary source
HGNC:HGNC:34298
See related
Ensembl:ENSG00000188306 AllianceGenome:HGNC:34298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC64
Summary
Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 1.1), colon (RPKM 0.3) and 5 other tissues See more
Orthologs
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Genomic context

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See LRRIQ4 in Genome Data Viewer
Location:
3q26.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (169812870..169837773)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (172597096..172621997)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (169530658..169555561)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:169490847-169491350 Neighboring gene tRNA-Val (anticodon AAC) 1-1 Neighboring gene myoneurin Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 3:169512145 Neighboring gene leucine rich repeat containing 34 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 3:169524016 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 3:169526272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20788 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:169564950-169565107 Neighboring gene leucine rich repeat containing 31 Neighboring gene keratin 18 pseudogene 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Leucine-rich repeat glycoproteins of the extracellular matrix. Hocking AM, et al. Matrix Biol, 1998 Apr. PMID 9628249
  2. Sequence motifs for calmodulin recognition. Rhoads AR, et al. FASEB J, 1997 Apr. PMID 9141499
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Wang T, et al. Neurobiol Aging, 2015 Jan. PMID 25192599
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
  5. The leucine-rich repeat as a protein recognition motif. Kobe B, et al. Curr Opin Struct Biol, 2001 Dec. PMID 11751054

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat and IQ domain-containing protein 4
Names
leucine rich repeat containing 64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080460.3 → NP_001073929.1  leucine-rich repeat and IQ domain-containing protein 4

    See identical proteins and their annotated locations for NP_001073929.1

    Status: VALIDATED

    Source sequence(s)
    AC078795
    Consensus CDS
    CCDS46951.1
    UniProtKB/Swiss-Prot
    A6NIV6
    UniProtKB/TrEMBL
    A0A8I5KNZ9
    Related
    ENSP00000342188.6, ENST00000340806.7
    Conserved Domains (3) summary
    cd00116
    Location:117 → 360
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:120 → 143
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:234 → 315
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    169812870..169837773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512749.2 → XP_011511051.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X2

    Conserved Domains (3) summary
    cd00116
    Location:117 → 394
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:190 → 212
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:234 → 315
    LRR_8; Leucine rich repeat

  2. XM_011512748.2 → XP_011511050.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011511050.1

    UniProtKB/Swiss-Prot
    A6NIV6
    UniProtKB/TrEMBL
    A0A8I5KNZ9
    Conserved Domains (3) summary
    cd00116
    Location:117 → 360
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:120 → 143
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:234 → 315
    LRR_8; Leucine rich repeat

  3. XM_006713613.5 → XP_006713676.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006713676.1

    UniProtKB/Swiss-Prot
    A6NIV6
    UniProtKB/TrEMBL
    A0A8I5KNZ9
    Related
    ENSP00000508855.1, ENST00000691416.1
    Conserved Domains (3) summary
    cd00116
    Location:117 → 360
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:120 → 143
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:234 → 315
    LRR_8; Leucine rich repeat

RNA

  1. XR_924128.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    172597096..172621997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346426.1 → XP_054202401.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X2

  2. XM_054346424.1 → XP_054202399.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    A6NIV6

  3. XM_054346425.1 → XP_054202400.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    A6NIV6

RNA

  1. XR_008486711.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NIV6.2 GenPept UniProtKB/Swiss-Prot:A6NIV6

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