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Myo31DF Myosin 31DF [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34445, updated on 2-Nov-2024

Summary

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Official Symbol
Myo31DFprovided by FlyBase
Official Full Name
Myosin 31DFprovided by FlyBase
Primary source
FLYBASE:FBgn0086347
Locus tag
Dmel_CG7438
See related
AllianceGenome:FB:FBgn0086347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7438; Dm IA; Dmel\CG7438; DmIA; DroMIA; IA; mhc1; Mhc1; Myo-IA; Myo1a; Myo1A; myo1D; Myo1D; myo31DF; MyoIA; MYOIA; myoID; MyoID; souther
Summary
Enables microfilament motor activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in digestive tract development; imaginal disc-derived male genitalia morphogenesis; and mesoderm development. Located in cell cortex. Is expressed in several structures, including embryonic/larval midgut primordium; enterocyte; glomerulus; gut section; and larval imaginal tissue. Orthologous to several human genes including MYO1G (myosin IG). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Myo31DF in Genome Data Viewer
Location:
31F1-31F4; 2-43 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10491814..10506779, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10491814..10506779, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Grip75 Neighboring gene Component of oligomeric golgi complex 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44224 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fatty acid transport protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Left-right asymmetry is formed in individual cells by intrinsic cell chirality. Hatori R, et al. Mech Dev, 2014 Aug. PMID 24800645
  2. Proper direction of male genitalia is prerequisite for copulation in Drosophila, implying cooperative evolution between genitalia rotation and mating behavior. Inatomi M, et al. Sci Rep, 2019 Jan 18. PMID 30659250, Free PMC Article
  3. Left-right Myosin-Is, Myosin1C, and Myosin1D exhibit distinct single molecule behaviors on the plasma membrane of Drosophila macrophages. Utsunomiya S, et al. Genes Cells, 2024 May. PMID 38454557
  4. Characterization of myosin-IA and myosin-IB, two unconventional myosins associated with the Drosophila brush border cytoskeleton. Morgan NS, et al. Dev Biol, 1995 Nov. PMID 7589814
  5. The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB. Morgan NS, et al. J Mol Biol, 1994 Jun 10. PMID 8201616

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results reveal the molecular motor Myo1D as a chiral determinant that is sufficient to break symmetry at all biological scales through chiral interaction with the actin cytoskeleton.
    Title: Molecular to organismal chirality is induced by the conserved myosin 1D.
  2. Myo31DF-overexpressing cells suggest that cell-shape chirality was established in each cell and reflects intrinsic planar cell chirality.
    Title: Left-right asymmetry is formed in individual cells by intrinsic cell chirality.
  3. DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment.
    Title: DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment.
  4. left-right(LR)directional rotation of hindgut epithelial tube; DECad is distributed to cell boundaries with LR asymmetry which is responsible for planar cell-shape chirality formation; myosin ID switches LR polarity found in PCC and in DE-Cad distribution
    Title: Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis.
  5. the organ specificities of the Myo31DF and Myo61F activities depended on their head regions
    Title: Head region of unconventional myosin I family members is responsible for the organ-specificity of their roles in left-right polarity in Drosophila.
  6. Myo31DF interacts and colocalizes with beta-catenin, suggesting that situs inversus genes can direct left-right development through the adherens junction
    Title: Type ID unconventional myosin controls left-right asymmetry in Drosophila.
  7. the actin cytoskeleton and myosin I proteins may be crucial for generating left-right asymmetry in invertebrates
    Title: An unconventional myosin in Drosophila reverses the default handedness in visceral organs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables microfilament motor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of digestive tract left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hindgut development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin 31DF
Names
CG7438-PA
CG7438-PB
CG7438-PC
Myo31DF-PA
Myo31DF-PB
Myo31DF-PC
Myosin31DF
myosin 1D
myosin 1a
myosin I
myosin IA
myosin ID
myosin-IA
myosin1A
souther
type ID unconventional myosin 31DF
unconventional myosin 31DF
NP_001188784.1
NP_523538.1
NP_723596.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10491814..10506779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078814.4 → NP_523538.1  myosin 31DF, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523538.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0K5, M9MRS7, Q23978
    Related
    FBpp0079625
    Conserved Domains (3) summary
    smart00242
    Location:6 → 690
    MYSc; Myosin. Large ATPases
    cd01378
    Location:21 → 677
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:801 → 983
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  2. NM_001201855.2 → NP_001188784.1  myosin 31DF, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188784.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0K5, M9MRS7, Q23978
    Conserved Domains (3) summary
    smart00242
    Location:6 → 690
    MYSc; Myosin. Large ATPases
    cd01378
    Location:21 → 677
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:801 → 983
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  3. NM_164933.3 → NP_723596.1  myosin 31DF, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723596.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0K5, M9MRS7, Q23978
    Related
    FBpp0079626
    Conserved Domains (3) summary
    smart00242
    Location:6 → 690
    MYSc; Myosin. Large ATPases
    cd01378
    Location:21 → 677
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:801 → 983
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23978.1 Q23978

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