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Mdh1 Malate dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34414, updated on 2-Nov-2024

Summary

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Official Symbol
Mdh1provided by FlyBase
Official Full Name
Malate dehydrogenase 1provided by FlyBase
Primary source
FLYBASE:FBgn0262782
Locus tag
Dmel_CG5362
See related
AllianceGenome:FB:FBgn0262782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5362; cMdh; CT17038; Dmel\CG5362; Mdh; MDH; Mdh-1; MDH-1; MDH1; Mdh2; MdhD; Q9VKX2; sMdh
Summary
Enables L-malate dehydrogenase (NAD+) activity. Involved in NADH metabolic process; malate metabolic process; and oxaloacetate metabolic process. Located in cytosol. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 88. Orthologous to human MDH1 (malate dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Mdh1 in Genome Data Viewer
Location:
31E1-31E1; 2-42 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10393774..10396332, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10393774..10396332, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene daughterless Neighboring gene antisense RNA:CR45789 Neighboring gene CCR4-NOT transcription complex subunit 4 Neighboring gene uncharacterized protein Neighboring gene Like Sm protein 4 Neighboring gene Ionotropic receptor 31a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative analysis of malate dehydrogenases of Drosophila melanogaster. O'Brien SJ. Biochem Genet, 1973 Oct. PMID 4201525
  2. Purification and properties of Drosophila malate dehydrogenases. McReynolds MS, et al. Biochim Biophys Acta, 1970 Feb 11. PMID 4313528
  3. Biochemical studies of supernatant malate dehydrogenase allozymes in Drosophila melanogaster. Alahiotis S. Comp Biochem Physiol B, 1979. PMID 45555
  4. Isozyme variability in species of the genus Drosophila. VII. Genotype-environment relationships in populations of D. melanogaster from the Eastern United States. Johnson FM, et al. Biochem Genet, 1973 Oct. PMID 4201524
  5. Ecdysone-modulated response of Drosophila cytosolic malate dehydrogenase to juvenile hormone. Farkas R, et al. Arch Insect Biochem Physiol, 1997. PMID 9131782

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-malate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-malate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-malate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADH metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADH metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in malate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oxaloacetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oxaloacetate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
malate dehydrogenase 1
Names
CG5362-PA
CG5362-PB
Mdh1-PA
Mdh1-PB
cytoplasmic Mdh
cytosolic malate dehydrogenase
malate dehydrogenase
malic DH
NP_001285803.1
NP_609394.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10393774..10396332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298874.1 → NP_001285803.1  malate dehydrogenase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285803.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQS7, Q9VKX2
    Conserved Domains (2) summary
    TIGR01758
    Location:6 → 328
    MDH_euk_cyt; malate dehydrogenase, NAD-dependent
    cd01336
    Location:3 → 327
    MDH_cytoplasmic_cytosolic; Cytoplasmic and cytosolic Malate dehydrogenases

  2. NM_135550.2 → NP_609394.1  malate dehydrogenase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609394.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQS7, Q9VKX2
    Related
    FBpp0079640
    Conserved Domains (2) summary
    TIGR01758
    Location:6 → 328
    MDH_euk_cyt; malate dehydrogenase, NAD-dependent
    cd01336
    Location:3 → 327
    MDH_cytoplasmic_cytosolic; Cytoplasmic and cytosolic Malate dehydrogenases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MQS7 Q8MQS7
Q9VKX2 Q9VKX2

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