Cdk5alpha Cdk5 activator-like protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cdk5alphaprovided by FlyBase
Official Full Name: Cdk5 activator-like proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0027491
Locus tag: Dmel_CG5387
See related: AllianceGenome:FB:FBgn0027491
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cdk5a; CG5387; D-p35; dCdk5alpha; Dmel\CG5387; Dp35; p25; p35; P35; p35-21C; p35-31C
Summary: Enables cyclin-dependent protein serine/threonine kinase activator activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; melanotic encapsulation of foreign target; and motor neuron axon guidance. Located in dendrite; growth cone; and neuronal cell body. Part of protein kinase 5 complex. Is expressed in embryonic/larval central nervous system and embryonic/larval sense organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10308131..10310956, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10308131..10310956, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Cdk5alpha-mediated neurodegeneration results from accelerated aging, in combination with cell-autonomous neuronal insults.
Title: Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
part_of protein kinase 5 complex	IEA Inferred from Electronic Annotation more info
part_of protein kinase 5 complex	IPI Inferred from Physical Interaction more info	PubMed

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