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IP3K1 Inositol 1,4,5-triphosphate kinase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34300, updated on 14-Nov-2024

Summary

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Official Symbol
IP3K1provided by FlyBase
Official Full Name
Inositol 1,4,5-triphosphate kinase 1provided by FlyBase
Primary source
FLYBASE:FBgn0032147
Locus tag
Dmel_CG4026
See related
AllianceGenome:FB:FBgn0032147
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.189; CG4026; D-IP3K1; Dmel\CG4026; dmIP3Kalpha; dmIP[[3]]Kalpha; Ip3k1; IP3KI; IP[[3]]K-1; UY530
Summary
Predicted to enable inositol tetrakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Involved in response to oxidative stress. Located in cytoplasm. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See IP3K1 in Genome Data Viewer
Location:
30C9-30D1; 2-36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9782384..9788499)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9782384..9788499)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pickpocket 18 Neighboring gene uncharacterized protein Neighboring gene pickpocket 11 Neighboring gene pickpocket 16 Neighboring gene hairpin RNA:CR18854 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Inositol 1,4,5-triphosphate kinase1 gene affects olfactory reception in Drosophila melanogaster. Gomez-Diaz C, et al. Behav Genet, 2006 Mar. PMID 16463070
  2. Regulation of inositol 1,4,5-trisphosphate 3-kinases by calcium and localization in cells. Lloyd-Burton SM, et al. J Biol Chem, 2007 Mar 30. PMID 17284449
  3. The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development. Dean DM, et al. G3 (Bethesda), 2015 Nov 27. PMID 26613949, Free PMC Article
  4. Control of oxidative stress resistance by IP3 kinase in Drosophila melanogaster. Monnier V, et al. Free Radic Biol Med, 2002 Nov 1. PMID 12398933
  5. Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Monnier V, et al. Genesis, 2002 Sep-Oct. PMID 12324953

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IP(3)K-1 modulates epithelial cell apoptosis without involvement of bcl-2-type proteins.
    Title: Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila.
  2. the major route of IP6 synthesis depends on the activities of dmIpk2 and dmIpk1, but not dmIP3K, offering a new role for IP3K in the genesis of higher IP messengers
    Title: A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inositol 1,4,5-triphosphate kinase 1
Names
CG4026-PA
CG4026-PB
IP3 kinase 1
IP3K1-PA
IP3K1-PB
inositol 1,4,5-triphosphate kinase1
NP_001245954.1
NP_609313.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9782384..9788499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135469.4 → NP_609313.2  inositol 1,4,5-triphosphate kinase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609313.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95R55, Q9VL83
    Related
    FBpp0079465
    Conserved Domains (1) summary
    pfam03770
    Location:220 → 426
    IPK; Inositol polyphosphate kinase

  2. NM_001259025.1 → NP_001245954.1  inositol 1,4,5-triphosphate kinase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245954.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6W4K9, M9ND56
    Conserved Domains (1) summary
    pfam03770
    Location:97 → 303
    IPK; Inositol polyphosphate kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9ND56 M9ND56
Q95R55 Q95R55
Q9VL83 Q9VL83

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