Apoltp Apolipoprotein lipid transfer particle [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Apoltpprovided by FlyBase
Official Full Name: Apolipoprotein lipid transfer particleprovided by FlyBase
Primary source: FLYBASE:FBgn0032136
Locus tag: Dmel_CG15828
See related: AllianceGenome:FB:FBgn0032136
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: apoltp; apoLTP; ApoLTP; ApoLTPI; ApoLTPII; CG15828; CT39214; Dmel\CG15828; ltp; Ltp; LTP
Summary: Enables lipid transporter activity and lipoprotein particle receptor binding activity. Involved in acylglycerol transport; positive regulation of lipid transport; and sterol transport. Located in basal part of cell; extracellular space; and plasma membrane. Is expressed in several structures, including epithelium; fat body; germline cell; gut section; and hemolymph. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9634179..9656026)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9634179..9656026)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables lipid transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipoprotein particle receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acylglycerol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transport across blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain