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PIG-U Phosphatidylinositol glycan anchor biosynthesis class U [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34185, updated on 18-Sep-2024

Summary

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Official Symbol
PIG-Uprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class Uprovided by FlyBase
Primary source
FLYBASE:FBgn0032052
Locus tag
Dmel_CG13089
See related
AllianceGenome:FB:FBgn0032052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13089; Dmel\CG13089; PIGU
Summary
Involved in GPI anchor biosynthetic process. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum and nuclear membrane. Is expressed in adult head and organism. Orthologous to human PIGU (phosphatidylinositol glycan anchor biosynthesis class U). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See PIG-U in Genome Data Viewer
Location:
29D4-29D4; 2-33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8515096..8516755)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8515096..8516755)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene Ubiquitin-like activating enzyme 4 Neighboring gene Sgroppino

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stability of the transamidase complex catalyzing GPI anchoring of proteins. Kawaguchi K, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30914202
  2. Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila. Kawaguchi K, et al. FEBS Lett, 2021 Apr. PMID 33496978
  3. Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements. Swain A, et al. PLoS Genet, 2016 Sep. PMID 27662615, Free PMC Article
  4. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  5. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Hollien J, et al. Science, 2006 Jul 7. PMID 16825573

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of GPI anchor to protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GPI-anchor transamidase complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol glycan anchor biosynthesis class U
Names
CG13089-PA
PIG-U-PA
phosphatidylinositol glycan anchor biosynthesis, class U
phosphatidylinositol glycan anchor biosynthesis, class U ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8515096..8516755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135394.3 → NP_609238.1  phosphatidylinositol glycan anchor biosynthesis class U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609238.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLK0
    Related
    FBpp0079294
    Conserved Domains (1) summary
    pfam06728
    Location:10 → 386
    PIG-U; GPI transamidase subunit PIG-U
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLK0 Q9VLK0

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