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EBLN1 endogenous Bornavirus like nucleoprotein 1 [ Homo sapiens (human) ]

Gene ID: 340900, updated on 17-Sep-2024

Summary

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Official Symbol
EBLN1provided by HGNC
Official Full Name
endogenous Bornavirus like nucleoprotein 1provided by HGNC
Primary source
HGNC:HGNC:39430
See related
Ensembl:ENSG00000223601 MIM:613249; AllianceGenome:HGNC:39430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBLN-1
Orthologs
all
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Genomic context

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See EBLN1 in Genome Data Viewer
Location:
10p12.31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (22208475..22218015, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (22227526..22237074, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (22497404..22506944, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C1 Neighboring gene RN7SK pseudogene 37 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3124 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:22292323-22292823 Neighboring gene Sharpr-MPRA regulatory region 4958 Neighboring gene nonconserved acetylation island sequence 68 enhancer Neighboring gene Sharpr-MPRA regulatory region 4688 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:22339665-22339854 Neighboring gene MPRA-validated peak904 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22417997-22418608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3127 Neighboring gene MPRA-validated peak905 silencer Neighboring gene MPRA-validated peak906 silencer Neighboring gene adiponectin receptor 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2201 Neighboring gene tRNA-Asn (anticodon GTT) 2-3 Neighboring gene proteasome activator subunit 2 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability. Myers KN, et al. Sci Rep, 2016 Oct 14. PMID 27739501, Free PMC Article
  2. Comprehensive analysis of endogenous bornavirus-like elements in eukaryote genomes. Horie M, et al. Philos Trans R Soc Lond B Biol Sci, 2013 Sep 19. PMID 23938751, Free PMC Article
  3. No evidence for natural selection on endogenous borna-like nucleoprotein elements after the divergence of Old World and New World monkeys. Kobayashi Y, et al. PLoS One, 2011. PMID 21912690, Free PMC Article
  4. Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells. He P, et al. Int J Mol Sci, 2016 Mar 24. PMID 27023521, Free PMC Article
  5. Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. Belyi VA, et al. PLoS Pathog, 2010 Jul 29. PMID 20686665, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. human EBLN1 possesses important cellular functions within human cells.
    Title: The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability.
  2. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women.
    Title: Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.
  3. Numerous genes were dysregulated by Endogenous bornavirus-like nucleoprotein 1 silencing, some of which may be key target genes of Rho family GTPase 3, oncostatin M receptor, and cAMP responsive element binding protein 3-like 2 protein.
    Title: Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
endogenous Bornavirus-like nucleoprotein 1
Names
endogenous Borna-like N element-1
endogenous Borna-like N element-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199938.2 → NP_001186867.1  endogenous Bornavirus-like nucleoprotein 1

    See identical proteins and their annotated locations for NP_001186867.1

    Status: VALIDATED

    Source sequence(s)
    AL157831
    Consensus CDS
    CCDS60498.1
    UniProtKB/Swiss-Prot
    P0CF75, S4R316
    Conserved Domains (1) summary
    pfam06407
    Location:18 → 366
    BDV_P40; Borna disease virus P40 protein

  2. NM_001394757.1 → NP_001381686.1  endogenous Bornavirus-like nucleoprotein 1

    Status: VALIDATED

    Source sequence(s)
    AL157831
    Consensus CDS
    CCDS60498.1
    UniProtKB/Swiss-Prot
    P0CF75, S4R316
    Related
    ENSP00000473842.1, ENST00000422359.3
    Conserved Domains (1) summary
    pfam06407
    Location:18 → 366
    BDV_P40; Borna disease virus P40 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    22208475..22218015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    22227526..22237074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CF75.2 GenPept UniProtKB/Swiss-Prot:P0CF75

Gene LinkOut

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