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Sumo Small ubiquitin like modifier [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33981, updated on 2-Nov-2024

Summary

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Official Symbol
Sumoprovided by FlyBase
Official Full Name
Small ubiquitin like modifierprovided by FlyBase
Primary source
FLYBASE:FBgn0264922
Locus tag
Dmel_CG4494
See related
AllianceGenome:FB:FBgn0264922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey240; CG4494; Dm0342; Dmel\CG4494; Dmsmt3; DmSmt3; DmSUMO-1; dsmt3; dSmt3; dSUMO; l(2)04493; l(2)SH0182; l(2)SH2 0182; smt3; Smt3; SMT3; sumo; SUMO
Summary
Enables protein tag activity. Involved in several processes, including dorsal appendage formation; neuron projection morphogenesis; and positive regulation of signal transduction. Located in condensed chromosome; midbody; and nucleolus. Part of outer kinetochore. Is expressed in several structures, including adult head; adult heart; embryonic cortex; germarium; and germline cell. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus 5. Orthologous to human SUMO2 (small ubiquitin like modifier 2); SUMO3 (small ubiquitin like modifier 3); and SUMO4 (small ubiquitin like modifier 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Sumo in Genome Data Viewer
Location:
27C7-27C7; 2-23 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6966780..6967644, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6966780..6967644, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene 3-Hydroxymethyl-3-methylglutaryl-CoA lyase Neighboring gene septin interacting protein 2 Neighboring gene Coproporphyrinogen oxidase Neighboring gene small ribonucleoprotein particle U1 subunit 70K Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the SMT3 cDNA and gene encoding ubiquitin-like protein from Drosophila melanogaster. Huang HW, et al. Biochem Mol Biol Int, 1998 Nov. PMID 9844739
  2. Tuning the HNN experiment: generation of serine-threonine check points. Chugh J, et al. J Biomol NMR, 2008 Feb. PMID 18163215
  3. Analysis of SUMOylated Proteins in Cells and In Vivo Using the bioSUMO Strategy. Pirone L, et al. Methods Mol Biol, 2016. PMID 27631805
  4. Conserved structural and dynamics features in the denatured states of drosophila SUMO, human SUMO and ubiquitin proteins: Implications to sequence-folding paradigm. Kumar D, et al. Proteins, 2009 Aug 1. PMID 19173311
  5. NMR-derived solution structure of SUMO from Drosophila melanogaster (dSmt3). Kumar D, et al. Proteins, 2009 Jun. PMID 19291740

See all (170) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells.
    Title: Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells.
  2. Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster.
    Title: Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster.
  3. Structural heterogeneity in the native-state ensemble of dSmt3, the only small ubiquitin-like modifier (SUMO) in Drosophila melanogaster, was investigated and compared with its human homologue SUMO1. The native state of dSmt3 seems more flexible in comparison to SUMO1.
    Title: NMR characterization of conformational fluctuations and noncovalent interactions of SUMO protein from Drosophila melanogaster (dSmt3).
  4. the pre-mRNA destabilization caused by Dsn depletion is rescued in DIP1 or Sumo heterozygous mutants, suggesting that Dsn is a negative regulator of DIP1. Our results reveal that under normal circumstances nascent transcripts are susceptible to DIP1-mediated degradation, however intronic sequences are protected by Dsn until intron excision has taken place
    Title: SON protects nascent transcripts from unproductive degradation by counteracting DIP1.
  5. Smt3, a homolog of small ubiquitin-like modifier (sumo), is a non-canonical RIDD target in Drosophila S2 cells. Unlike other RIDD targets, the sumo transcript does not stably associate with the ER membrane
    Title: Regulation of sumo mRNA during endoplasmic reticulum stress.
  6. SUMO conjugation is required for the assembly of Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation.
    Title: SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation.
  7. although knockdown of the homeodomain-interacting protein kinase (Hipk) suppresses Smt3 depletion-induced activation of JNK, Hipk overexpression synergistically enhances this type of JNK activation
    Title: Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.
  8. SUMO coordinates multiple regulatory processes during oogenesis and early embryogenesis
    Title: Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation.
  9. Drosophila p53 modification by SUMO modulates its transactivation and pro-apoptotic functions
    Title: Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions.
  10. Smt3 is required for the ecdysteroid synthesis pathway at the time of puparium formation.
    Title: Smt3 is required for Drosophila melanogaster metamorphosis.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

mobile_element

  • Loc: c6967586-6967536 mobile_element_type = transposon:mdg1{}5628

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tag activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in central nervous system projection neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Toll signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein modification process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pupariation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in syncytial blastoderm mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small ubiquitin like modifier
Names
CG4494-PA
CG4494-PB
SUMO
SUMO protein
Sumo-PA
Sumo-PB
lethal (2) SH0182
small Ubiquitin-like modifier
smt3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6966780..6967644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058063.4 → NP_477411.1  small ubiquitin like modifier, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O97102
    Related
    FBpp0078984
    Conserved Domains (1) summary
    cd16115
    Location:12 → 83
    Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins

  2. NM_001316383.1 → NP_001303312.1  small ubiquitin like modifier, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O97102
    Conserved Domains (1) summary
    cd16115
    Location:12 → 83
    Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97102 O97102

Gene LinkOut

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