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Fgop2 Fibroblast growth factor receptor 1 oncogene partner 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33971, updated on 28-Oct-2024

Summary

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Official Symbol
Fgop2provided by FlyBase
Official Full Name
Fibroblast growth factor receptor 1 oncogene partner 2provided by FlyBase
Primary source
FLYBASE:FBgn0031871
Locus tag
Dmel_CG10158
See related
AllianceGenome:FB:FBgn0031871
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10158; Dmel\CG10158; FGFR1OP2; FGOP2
Summary
Involved in negative regulation of hippo signaling. Part of FAR/SIN/STRIPAK complex. Is expressed in adult head and organism. Orthologous to several human genes including FGFR1OP2 (FGFR1 oncogene partner 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See Fgop2 in Genome Data Viewer
Location:
27C6-27C6; 2-23 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6943178..6945289, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6943178..6945289, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Heterogeneous nuclear ribonucleoprotein at 27C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene interference hedgehog Neighboring gene Gas41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ihog and Boi are essential for Hedgehog signaling in Drosophila. Camp D, et al. Neural Dev, 2010 Nov 2. PMID 21044292, Free PMC Article
  2. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex. Zheng Y, et al. Cell Rep, 2017 Dec 19. PMID 29262338, Free PMC Article
  3. A conserved STRIPAK complex is required for autophagy in muscle tissue. Guo Y, et al. Mol Biol Cell, 2023 Aug 1. PMID 37379167, Free PMC Article
  4. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Yao S, et al. Cell, 2006 Apr 21. PMID 16630821
  5. The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Yan D, et al. Development, 2010 Jun. PMID 20501592, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in negative regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction HGI PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 1 oncogene partner 2
Names
CG10158-PA
CG10158-PB
Fgop2-PA
Fgop2-PB
fibroblast growth factor receptor 1 oncogene partner 2 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6943178..6945289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273242.1 → NP_001260171.1  fibroblast growth factor receptor 1 oncogene partner 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260171.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VM65
    UniProtKB/TrEMBL
    M9PEZ2
    Conserved Domains (1) summary
    pfam05769
    Location:3 → 181
    DUF837; Protein of unknown function (DUF837)

  2. NM_135240.4 → NP_609084.1  fibroblast growth factor receptor 1 oncogene partner 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609084.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VM65
    UniProtKB/TrEMBL
    M9PEZ2
    Related
    FBpp0078994
    Conserved Domains (1) summary
    pfam05769
    Location:3 → 181
    DUF837; Protein of unknown function (DUF837)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEZ2 M9PEZ2
Q9VM65.1 Q9VM65

Gene LinkOut

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