ID1 inhibitor of DNA binding 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ID1provided by HGNC
Official Full Name: inhibitor of DNA binding 1provided by HGNC
Primary source: HGNC:HGNC:5360
See related: Ensembl:ENSG00000125968 MIM:600349; AllianceGenome:HGNC:5360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ID; bHLHb24
Summary: The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lung (RPKM 56.6), colon (RPKM 54.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (31605289..31606510)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (33329528..33330749)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (30193092..30194313)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ID1 expressing macrophages support cancer cell stemness and limit CD8[+] T cell infiltration in colorectal cancer.
Title: ID1 expressing macrophages support cancer cell stemness and limit CD8(+) T cell infiltration in colorectal cancer.
Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression.
Title: Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression.
The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
Title: The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
Abnormal regulation of miR-29b-ID1 signaling is involved in the process of decitabine resistance in leukemia cells.
Title: Abnormal regulation of miR-29b-ID1 signaling is involved in the process of decitabine resistance in leukemia cells.
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.
Title: Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.
ID1 marks the tumorigenesis of pancreatic ductal adenocarcinoma in mouse and human.
Title: ID1 marks the tumorigenesis of pancreatic ductal adenocarcinoma in mouse and human.
ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.
Title: ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.
Deubiquitinase USP8 increases ID1 stability and promotes esophageal squamous cell carcinoma tumorigenesis.
Title: Deubiquitinase USP8 increases ID1 stability and promotes esophageal squamous cell carcinoma tumorigenesis.
Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) modulates inhibitor of DNA binding 1 (ID1) to facilitate papillary thyroid carcinoma development by sponging microRNA-524-5p.
Title: Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) modulates inhibitor of DNA binding 1 (ID1) to facilitate papillary thyroid carcinoma development by sponging microRNA-524-5p.
ID1/ID3 mediate the contribution of skin fibroblasts to local nerve regeneration through Itga6 in wound repair.
Title: ID1/ID3 mediate the contribution of skin fibroblasts to local nerve regeneration through Itga6 in wound repair.

Submit: New GeneRIF Correction See all GeneRIFs (252)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates nerve growth factor (NGF)-induced ID1 expression in PC12 neuronal cells through a pathway that involves phosphorylation of Stat5a	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156147P2 (e-PCR)
- UniSTS:271379

WI-9304 (e-PCR)
- UniSTS:64649

PMC22262P1 (e-PCR)
- UniSTS:272102

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription regulator inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in blood vessel endothelial cell migration	TAS Traceable Author Statement more info	PubMed
involved_in blood vessel morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by transcription factor localization	TAS Traceable Author Statement more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-1

Names: class B basic helix-loop-helix protein 24; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein); inhibitor of DNA binding 1, HLH protein; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; inhibitor of differentiation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029639.1 RefSeqGene

Range

5007..6228

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002165.4 → NP_002156.2 DNA-binding protein inhibitor ID-1 isoform a

See identical proteins and their annotated locations for NP_002156.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a, also called ID-1H).

Source sequence(s)

AI304595, BC012420, DA839689

Consensus CDS

CCDS13185.1

UniProtKB/Swiss-Prot

A8K537, E1P5L4, O00651, O00652, P41134, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109

Related

ENSP00000365280.3, ENST00000376112.4

Conserved Domains (1) summary

cd19691
Location:62 → 113

bHLH_dnHLH_ID1; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins
NM_181353.3 → NP_851998.1 DNA-binding protein inhibitor ID-1 isoform b

See identical proteins and their annotated locations for NP_851998.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate segment compared to variant 1, that causes a frameshift. The resulting isoform (b, also called ID-1H') is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AI304595, BC012420, BI768231, BM856018

Consensus CDS

CCDS13186.1

UniProtKB/Swiss-Prot

P41134

Related

ENSP00000365273.3, ENST00000376105.4

Conserved Domains (1) summary

cd00083
Location:68 → 109

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...