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Morc3 microrchidia 3 [ Mus musculus (house mouse) ]

Gene ID: 338467, updated on 17-Aug-2024

Summary

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Official Symbol
Morc3provided by MGI
Official Full Name
microrchidia 3provided by MGI
Primary source
MGI:MGI:2136841
See related
Ensembl:ENSMUSG00000039456 AllianceGenome:MGI:2136841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NXP2; Zcwcc3; D16Jhu32e; 1110051N18Rik
Summary
Predicted to enable methylated histone binding activity. Acts upstream of or within post-embryonic development. Located in PML body. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human MORC3 (MORC family CW-type zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.1), CNS E11.5 (RPKM 7.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C4; 16 54.88 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (93629009..93672964)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (93832121..93876077)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5562 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:93711280-93711389 Neighboring gene STARR-positive B cell enhancer ABC_E1497 Neighboring gene STARR-seq mESC enhancer starr_41539 Neighboring gene predicted gene, 41501 Neighboring gene DOP1 leucine zipper like protein B Neighboring gene RIKEN cDNA 2310043M15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:93798797-93799098 Neighboring gene STARR-positive B cell enhancer ABC_E7479 Neighboring gene STARR-seq mESC enhancer starr_41543 Neighboring gene predicted gene, 30881 Neighboring gene STARR-positive B cell enhancer ABC_E7480 Neighboring gene STARR-positive B cell enhancer ABC_E3176 Neighboring gene STARR-seq mESC enhancer starr_41545 Neighboring gene STARR-positive B cell enhancer ABC_E3177 Neighboring gene STARR-seq mESC enhancer starr_41548 Neighboring gene chromatin assembly factor 1, subunit B Neighboring gene STARR-positive B cell enhancer mm9_chr16:93914500-93914801 Neighboring gene STARR-positive B cell enhancer ABC_E10925 Neighboring gene STARR-seq mESC enhancer starr_41549 Neighboring gene claudin 14 Neighboring gene predicted gene, 31012

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of MORC3 in silencing transposable elements in mouse embryonic stem cells. Desai VP, et al. Epigenetics Chromatin, 2021 Oct 27. PMID 34706774, Free PMC Article
  2. Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. Li S, et al. Proc Natl Acad Sci U S A, 2016 Aug 30. PMID 27528681, Free PMC Article
  3. Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase. Andrews FH, et al. Cell Rep, 2016 Sep 20. PMID 27653685, Free PMC Article
  4. Genome-wide ENU mutagenesis to reveal immune regulators. Nelms KA, et al. Immunity, 2001 Sep. PMID 11567631
  5. Two-step colocalization of MORC3 with PML nuclear bodies. Mimura Y, et al. J Cell Sci, 2010 Jun 15. PMID 20501696

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of MORC3 in silencing transposable elements in mouse embryonic stem cells.
    Title: The role of MORC3 in silencing transposable elements in mouse embryonic stem cells.
  2. Data show that the MORC3 N-terminal ATPase domain forms a dimer when bound to AMPPNP.
    Title: Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin.
  3. Data indicate that Morc3 mutation leads to altered nuclear localization of the protein, and upregulation of the IFN-beta /STAT1 pathway, which plays a critical role in the maintenance of bone homeostasis. These findings establish Morc3 as a previously unreported regulator of cortical bone homeostasis and haematopoietic stem cells niche, accompanied by altered bone cell differentiation.
    Title: Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation.
  4. MORC3 colocalizes with PML by a two-step molecular mechanism.
    Title: Two-step colocalization of MORC3 with PML nuclear bodies.
  5. MORC3 (microrchidia3)-ATPase activated p53 and induced cellular senescence in normal fibroblasts but not p53-/- fibroblasts
    Title: Dynamic regulation of p53 subnuclear localization and senescence by MORC3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within maintenance of protein location in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MORC family CW-type zinc finger protein 3
Names
nuclear matrix protein 2
zinc finger CW-type coiled-coil domain protein 3
zinc finger, CW-type with coiled-coil domain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045529.3 → NP_001038994.2  MORC family CW-type zinc finger protein 3

    Status: VALIDATED

    Source sequence(s)
    AK172896, BC098072
    Consensus CDS
    CCDS79490.1
    UniProtKB/Swiss-Prot
    A6H605, F7BJB9, Q4QQR6, Q6A0C2, Q8R0R0
    Related
    ENSMUSP00000144369.2, ENSMUST00000202261.5
    Conserved Domains (4) summary
    pfam07496
    Location:409 → 446
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:29 → 136
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl09111
    Location:768 → 875
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl21462
    Location:698 → 721
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    93629009..93672964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523060.4 → XP_006523123.1  MORC family CW-type zinc finger protein 3 isoform X1

    Conserved Domains (4) summary
    TIGR02168
    Location:629 → 810
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07496
    Location:340 → 377
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:180 → 313
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    cl00075
    Location:14 → 66
    HATPase; Histidine kinase-like ATPase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F7BJB9.1 GenPept UniProtKB/Swiss-Prot:F7BJB9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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