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ifc infertile crescent [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33836, updated on 2-Nov-2024

Summary

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Official Symbol
ifcprovided by FlyBase
Official Full Name
infertile crescentprovided by FlyBase
Primary source
FLYBASE:FBgn0001941
Locus tag
Dmel_CG9078
See related
AllianceGenome:FB:FBgn0001941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9078; des; des-1; Des-1; DES-1; des1; Des1; Dmel\CG9078; Ifc; l(2)26Ab; l(2)gdh-2; ms(2)04875
Summary
Enables sphingolipid delta-4 desaturase activity. Involved in negative regulation of lipophagy. Located in endoplasmic reticulum and late endosome. Is expressed in several structures, including Malpighian tubule primordium; circulatory system primordium; embryonic/larval midgut primordium; germline cell; and gut section. Used to study neurodegenerative disease and obesity. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 18. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1) and DEGS2 (delta 4-desaturase, sphingolipid 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See ifc in Genome Data Viewer
Location:
26B2-26B2; 2-18 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5986348..5988854)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5986348..5988854)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene chickadee Neighboring gene eukaryotic translation initiation factor 4A Neighboring gene Lysine demethylase 5 Neighboring gene Tetraspanin 26A Neighboring gene beta galactosidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Degenerative spermatocyte, a novel gene encoding a transmembrane protein required for the initiation of meiosis in Drosophila spermatogenesis. Endo K, et al. Mol Gen Genet, 1996 Nov 27. PMID 9003299
  2. A new retroposed gene in Drosophila heterochromatin detected by microarray-based comparative genomic hybridization. Fan C, et al. J Mol Evol, 2007 Feb. PMID 17177089
  3. Endosymbiotic origins of sex. Bazinet C. Bioessays, 2004 May. PMID 15112236
  4. Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation in vivo. Jung WH, et al. EMBO Rep, 2017 Jul. PMID 28507162, Free PMC Article
  5. The Des-1 protein, required for central spindle assembly and cytokinesis, is associated with mitochondria along the meiotic spindle apparatus and with the contractile ring during male meiosis in Drosophila melanogaster. Basu J, et al. Mol Gen Genet, 1998 Oct. PMID 9819060

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress.
    Title: Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress.
  2. Systemic and heart autonomous effects of sphingosine Delta4 desaturase deficiency in lipotoxic cardiac pathophysiology.
    Title: Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sphingolipid delta-4 desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingolipid delta-4 desaturase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sphingolipid delta-4 desaturase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of lipophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
infertile crescent
Names
CG9078-PA
CG9078-PB
degenerating spermatocyte
degenerative spermatocyte
ifc-PA
ifc-PB
sphingolipid delta 4 desaturase
sphingosine Delta-4 desaturase
NP_001260118.1
NP_476594.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5986348..5988854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057246.5 → NP_476594.1  infertile crescent, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476594.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94515
    Related
    FBpp0078810
    Conserved Domains (2) summary
    cd03508
    Location:26 → 315
    Delta4-sphingolipid-FADS-like; The Delta4-sphingolipid Fatty Acid Desaturase (Delta4-sphingolipid-FADS)-like CD includes the integral-membrane enzymes, dihydroceramide Delta-4 desaturase, involved in the synthesis of sphingosine; and the human membrane fatty acid (lipid) desaturase ...
    pfam08557
    Location:6 → 42
    Lipid_DES; Sphingolipid Delta4-desaturase (DES)

  2. NM_001273189.1 → NP_001260118.1  infertile crescent, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260118.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PC47
    Conserved Domains (1) summary
    cl00615
    Location:1 → 96
    Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PC47 M9PC47
Q94515.1 Q94515

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