fgb fibrinogen beta chain [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fgbprovided by ZNC
Official Full Name: fibrinogen beta chainprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9261
See related: Ensembl:ENSDARG00000008969 AllianceGenome:ZFIN:ZDB-GENE-030131-9261
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77116; wu:fa55c11
Summary: Predicted to enable signaling receptor binding activity. Acts upstream of or within blood coagulation, fibrin clot formation. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (10051806..10059430)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (9367695..9375319)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fgb (e-PCR), detects polymorphism
- UniSTS:205634

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation, fibrin clot formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood coagulation, fibrin clot formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood coagulation, fibrin clot formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet activation	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein polymerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of fibrinogen complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibrinogen beta chain

Names: fibrinogen, B beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212774.1 → NP_997939.1 fibrinogen beta chain precursor

See identical proteins and their annotated locations for NP_997939.1

Status: PROVISIONAL

Source sequence(s)

BC066629

UniProtKB/TrEMBL

A0A8M1PI99, Q6NYE1

Related

ENSDARP00000016228.6, ENSDART00000011701.7

Conserved Domains (2) summary

pfam08702
Location:87 → 229

Fib_alpha; Fibrinogen alpha/beta chain family

cl00085
Location:232 → 481

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...