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myl12.2 myosin, light chain 12, genome duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 337084, updated on 2-Nov-2024

Summary

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Official Symbol
myl12.2provided by ZNC
Official Full Name
myosin, light chain 12, genome duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9028
See related
Ensembl:ENSDARG00000025326 AllianceGenome:ZFIN:ZDB-GENE-030131-9028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mlc12.2; wu:fa97a12; si:dkey-216e9.5
Summary
Predicted to enable calcium ion binding activity. Predicted to be active in cytoplasm. Orthologous to human MYL12A (myosin light chain 12A) and MYL12B (myosin light chain 12B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See myl12.2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30910131..30912932, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30926598..30929399, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 5a Neighboring gene BCL2 associated athanogene 1 Neighboring gene myomesin 1a (skelemin) Neighboring gene lipin 2 Neighboring gene elastin microfibril interfacer 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Qian W, et al. Curr Biol, 2024 Jan 22. PMID 38096821,
  2. Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms. Chen Z, et al. Cardiovasc Res, 2008 Jul 1. PMID 18343897, Free PMC Article
  3. Duplication of a Single myhz1.1 Gene Facilitated the Ability of Goldfish (Carassius auratus) to Alter Fast Muscle Contractile Properties With Seasonal Temperature Change. Garcia de la Serrana D, et al. Front Physiol, 2018. PMID 30568597, Free PMC Article
  4. Rear traction forces drive adherent tissue migration in vivo. Yamaguchi N, et al. Nat Cell Biol, 2022 Feb. PMID 35165417, Free PMC Article
  5. Microarray gene expression profiling during the segmentation phase of zebrafish development. Linney E, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2004 Jul. PMID 15533793

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin, light chain 12, genome duplicate 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130589.2 → NP_001124061.1  myosin, light chain 12, genome duplicate 2

    See identical proteins and their annotated locations for NP_001124061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL929096, EH548769
    UniProtKB/TrEMBL
    A0A8M1P1B1, B3DKC6
    Related
    ENSDARP00000152171.1, ENSDART00000188653.1
    Conserved Domains (1) summary
    COG5126
    Location:19 → 169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_001291711.1 → NP_001278640.1  myosin, light chain 12, genome duplicate 2

    See identical proteins and their annotated locations for NP_001278640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    EB844949, EH548769
    UniProtKB/TrEMBL
    A0A8M1P1B1, B3DKC6
    Related
    ENSDARP00000117880.1, ENSDART00000141669.2
    Conserved Domains (1) summary
    COG5126
    Location:19 → 169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    30910131..30912932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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