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betaggt-I beta subunit of type I geranylgeranyl transferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33704, updated on 14-Nov-2024

Summary

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Official Symbol
betaggt-Iprovided by FlyBase
Official Full Name
beta subunit of type I geranylgeranyl transferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0015000
Locus tag
Dmel_CG3469
See related
AllianceGenome:FB:FBgn0015000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
beta GGT-I; beta-GGT; betaggt; betaGGT; betaGGT-I; betaGGTI; bro3; CG3469; Dmel\CG3469; ggt-1; ggt-I; ggt1; GGT1; SR2-2
Summary
Predicted to enable protein geranylgeranyltransferase activity. Predicted to contribute to CAAX-protein geranylgeranyltransferase activity. Involved in embryonic heart tube development. Predicted to be part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See betaggt-I in Genome Data Viewer
Location:
25B4-25B4; 2-14 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4945579..4948324)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4945579..4948324)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Salivary gland secretion 1 Neighboring gene sayonara Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene jetlag Neighboring gene Jonah 25Biii Neighboring gene Jonah 25Bii

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metabolic control of YAP and TAZ by the mevalonate pathway. Sorrentino G, et al. Nat Cell Biol, 2014 Apr. PMID 24658687
  2. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Yi P, et al. Science, 2006 Sep 1. PMID 16857902
  3. Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo. Sawyer JK, et al. PLoS Genet, 2020 Dec. PMID 33296356, Free PMC Article
  4. An ABC transporter controls export of a Drosophila germ cell attractant. Ricardo S, et al. Science, 2009 Feb 13. PMID 19213920, Free PMC Article
  5. KSR, a novel protein kinase required for RAS signal transduction. Therrien M, et al. Cell, 1995 Dec 15. PMID 8521512

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction HGI PubMed 
involved_in protein geranylgeranylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CAAX-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAAX-protein geranylgeranyltransferase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta subunit of type I geranylgeranyl transferase
Names
CG3469-PA
CG3469-PB
betaggt-I-PA
betaggt-I-PB
suppressor of Ras1 2-2
type I geranylgeranyl transferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4945579..4948324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080361.3 → NP_525100.2  beta subunit of type I geranylgeranyl transferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525100.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24172, Q24173
    Related
    FBpp0078630
    Conserved Domains (2) summary
    COG5029
    Location:10 → 336
    CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
    cd02895
    Location:14 → 321
    GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

  2. NM_001273132.1 → NP_001260061.1  beta subunit of type I geranylgeranyl transferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260061.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEL6, Q24172
    Conserved Domains (2) summary
    COG5029
    Location:10 → 336
    CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
    cd02895
    Location:14 → 321
    GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEL6 M9PEL6
Q24172 Q24172
Q24173 Q24173

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