ch25hl1.1 cholesterol 25-hydroxylase like 1, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ch25hl1.1provided by ZNC
Official Full Name: cholesterol 25-hydroxylase like 1, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8617
See related: Ensembl:ENSDARG00000039381 AllianceGenome:ZFIN:ZDB-GENE-030131-8617
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Ch25h; ch25hc.1; ch25hc.2; wu:fa92a08; zgc:110696; si:dkey-24l11.8
Summary: Predicted to enable C-4 methylsterol oxidase activity and steroid hydroxylase activity. Predicted to be involved in cholesterol metabolic process and sterol biosynthetic process. Predicted to act upstream of or within steroid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in gill; intestine; kidney; liver; and spleen. Orthologous to human CH25H (cholesterol 25-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (26853892..26858973, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (26871514..26876595, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa92a08.x1 (e-PCR)
- UniSTS:189653

fa92a08.x1 (e-PCR)
- UniSTS:189654

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables C-4 methylsterol oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables steroid hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cholesterol 25-hydroxylase-like protein 1, member 1

Names: cholesterol 25-hydroxylase like 1, member 1

NP_001017865.1

EC 1.14.99.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017865.1 → NP_001017865.1 cholesterol 25-hydroxylase-like protein 1, member 1

See identical proteins and their annotated locations for NP_001017865.1

Status: PROVISIONAL

Source sequence(s)

BC092984

UniProtKB/Swiss-Prot

Q1LX56, Q567X1

Related

ENSDARP00000057552.2, ENSDART00000057553.4

Conserved Domains (2) summary

COG3000
Location:28 → 267

ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]

pfam04116
Location:131 → 265

FA_hydroxylase; Fatty acid hydroxylase superfamily