dpp decapentaplegic [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dppprovided by FlyBase
Official Full Name: decapentaplegicprovided by FlyBase
Primary source: FLYBASE:FBgn0000490
Locus tag: Dmel_CG9885
See related: AllianceGenome:FB:FBgn0000490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: blk; Bmp; BMP; CG9885; Dm-DPP; DmDPP; Dmel\CG9885; Dpp; DPP; DPP-C; Dpp/TGFbeta; Hin-d; ho; l(2)10638; l(2)22Fa; l(2)k17036; M(2)23AB; M(2)LS1; shv; Tg; TGF-b; TGF-beta; Tgfbeta; TGFbeta
Summary: Enables several functions, including heparin binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including embryonic morphogenesis; open tracheal system development; and regionalization. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Located in cell leading edge; dense core granule lumen; and extracellular space. Colocalizes with cytoneme. Is expressed in several structures, including anterior-posterior subdivision of organism; compartment boundary; epithelium; imaginal disc; and wing vein. Used to study juvenile polyposis syndrome. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); bone disease (multiple); cleft lip; hemochromatosis type 1; and orofacial cleft 11. Orthologous to human BMP2 (bone morphogenetic protein 2) and BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 22F1-22F3; 2-6 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2428372..2459823)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2428372..2459823)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization.
Title: Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization.
Bone morphogenetic protein signaling: the pathway and its regulation.
Title: Bone morphogenetic protein signaling: the pathway and its regulation.
Is Drosophila Dpp/BMP morphogen spreading required for wing patterning and growth?
Title: Is Drosophila Dpp/BMP morphogen spreading required for wing patterning and growth?
Deltex modulates Dpp morphogen gradient formation and affects Dpp signaling in Drosophila.
Title: Deltex modulates Dpp morphogen gradient formation and affects Dpp signaling in Drosophila.
Preformation and epigenesis converge to specify primordial germ cell fate in the early Drosophila embryo.
Title: Preformation and epigenesis converge to specify primordial germ cell fate in the early Drosophila embryo.
The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.
Title: The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.
Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc.
Title: Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc.
Dpp/TGFbeta-superfamily play a dual conserved role in mediating the damage response in the retina.
Title: Dpp/TGFβ-superfamily play a dual conserved role in mediating the damage response in the retina.
Decapentaplegic Acutely Defines the Connectivity of Central Pacemaker Neurons in Drosophila.
Title: Decapentaplegic Acutely Defines the Connectivity of Central Pacemaker Neurons in Drosophila.
Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.
Title: Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.

Submit: New GeneRIF Correction See all GeneRIFs (200)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0672 (e-PCR)
- UniSTS:55221

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables BMP receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables morphogen activity	IDA Inferred from Direct Assay more info	PubMed
enables morphogen activity	IGI Inferred from Genetic Interaction more info	PubMed
enables morphogen activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amnioserosa formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell chemotaxis involved in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ectodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusion cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genital disc anterior/posterior pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in genital disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genital disc sexually dimorphic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IEP Inferred from Expression Pattern more info	PubMed
involved_in labial disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal specification of dorsal/ventral axis, oocyte, soma encoded	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of salivary gland boundary specification	TAS Traceable Author Statement more info	PubMed
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in progression of morphogenetic furrow involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	TAS Traceable Author Statement more info	PubMed
involved_in regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of tube diameter, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spectrosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing and notum subfield formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zygotic specification of dorsal/ventral axis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoneme	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule lumen	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: decapentaplegic

Names: CG9885-PA; CG9885-PB; CG9885-PC; CG9885-PE; Decapentaplegic/Bone morphogenetic protein; Haplo-insufficient; blink; bone morphogenetic protein; bone morphogenic protein; dpp-PA; dpp-PB; dpp-PC; dpp-PE; heldout; shortvein; tegula

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2428372..2459823

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057963.5 → NP_477311.1 decapentaplegic, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477311.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V009, P07713, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6

Related

FBpp0077451

Conserved Domains (2) summary

smart00204
Location:487 → 588

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:225 → 444

TGFb_propeptide; TGF-beta propeptide
NM_164485.2 → NP_722810.1 decapentaplegic, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722810.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V009, P07713, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6

Related

FBpp0077452

Conserved Domains (2) summary

smart00204
Location:487 → 588

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:225 → 444

TGFb_propeptide; TGF-beta propeptide
NM_164486.2 → NP_722811.1 decapentaplegic, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722811.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V009, P07713, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6

Related

FBpp0077453

Conserved Domains (2) summary

smart00204
Location:487 → 588

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:225 → 444

TGFb_propeptide; TGF-beta propeptide
NM_164488.2 → NP_722813.1 decapentaplegic, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722813.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V009, P07713, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6

Related

FBpp0077455

Conserved Domains (2) summary

smart00204
Location:487 → 588

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:225 → 444

TGFb_propeptide; TGF-beta propeptide