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PIG-Wa Phosphatidylinositol glycan anchor biosynthesis class W a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33425, updated on 18-Sep-2024

Summary

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Official Symbol
PIG-Waprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class W aprovided by FlyBase
Primary source
FLYBASE:FBgn0031422
Locus tag
Dmel_CG9870
See related
AllianceGenome:FB:FBgn0031422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9870; Dmel\CG9870; PIG-W; PIGWWa
Summary
Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Predicted to be integral component of membrane. Is expressed in adult head. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See PIG-Wa in Genome Data Viewer
Location:
22E1-22E1; 2-6 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2383202..2384747)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2383202..2384747)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ataxin 7 Neighboring gene EGF-domain O-GlcNAc transferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selenoprotein dSelK in Drosophila elevates release of Ca2+ from endoplasmic reticulum by upregulating expression of inositol 1,4,5-tris-phosphate receptor. Ben SB, et al. Biochemistry (Mosc), 2011 Sep. PMID 22082272
  2. The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain. Mahr A, et al. Gene Expr Patterns, 2006 Mar. PMID 16378756
  3. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  4. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
  5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol glycan anchor biosynthesis class W a
Names
CG9870-PA
PIG-Wa-PA
NP_608679.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2383202..2384747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134835.2 → NP_608679.1  phosphatidylinositol glycan anchor biosynthesis class W a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608679.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQB8
    Related
    FBpp0077448
    Conserved Domains (1) summary
    cl02109
    Location:59 → 457
    GWT1; GWT1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQB8 Q9VQB8

Gene LinkOut

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