halo halo [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: haloprovided by FlyBase
Official Full Name: haloprovided by FlyBase
Primary source: FLYBASE:FBgn0001174
Locus tag: Dmel_CG7428
See related: AllianceGenome:FB:FBgn0001174
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7428; Dmel\CG7428
Summary: Enables kinesin binding activity. Involved in several processes, including lipid droplet transport along microtubule; lipid transport; and regulation of phosphorylation. Located in cytoplasm; lipid droplet; and nucleus. Is expressed in several structures, including anlage in statu nascendi; ectoderm anlage; extended germ band embryo; germ layer; and posterior endoderm anlage. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1517533..1518148, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1517533..1518148, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Halo and kinesin-1 are present in common protein complexes, Halo acts as a rate-limiting co-factor of kinesin-1.
Title: Temporal control of bidirectional lipid-droplet motion in Drosophila depends on the ratio of kinesin-1 and its co-factor Halo.
Halo acts as a directionality determinant for embryonic droplet transport.
Title: A determinant for directionality of organelle transport in Drosophila embryos.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables kinesin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid droplet transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed