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HSP90AB1 heat shock protein 90 alpha family class B member 1 [ Homo sapiens (human) ]

Gene ID: 3326, updated on 14-Nov-2024

Summary

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Official Symbol
HSP90AB1provided by HGNC
Official Full Name
heat shock protein 90 alpha family class B member 1provided by HGNC
Primary source
HGNC:HGNC:5258
See related
Ensembl:ENSG00000096384 MIM:140572; AllianceGenome:HGNC:5258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP84; HSPC2; HSPCB; D6S182; HSP90B
Summary
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues See more
Orthologs
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Genomic context

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See HSP90AB1 in Genome Data Viewer
Location:
6p21.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (44246194..44253883)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (44080360..44088031)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44213931..44221620)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene myomixer, myoblast fusion factor Neighboring gene RNA, 7SL, cytoplasmic 811, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr6:44181066-44181247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44184149-44185034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44185035-44185920 Neighboring gene Sharpr-MPRA regulatory region 7869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44191161-44192019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24631 Neighboring gene solute carrier family 29 member 1 (Augustine blood group) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44194558-44195156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44213140-44213894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44214649-44215403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44222709-44223424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44224854-44225567 Neighboring gene solute carrier family 35 member B2 Neighboring gene microRNA 4647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44232415-44232914 Neighboring gene NFKB inhibitor epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis. Tomcik M, et al. Ann Rheum Dis, 2014 Jun. PMID 23661493
  2. Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs. Phillips JJ, et al. J Mol Biol, 2007 Oct 5. PMID 17764690
  3. Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation. Heck AL, et al. Immunobiology, 2021 Mar. PMID 33639524
  4. Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations. Tomašič T, et al. Int J Mol Sci, 2020 Sep 20. PMID 32962253, Free PMC Article
  5. Heat shock protein-90 beta is expressed at the surface of multipotential mesenchymal precursor cells: generation of a novel monoclonal antibody, STRO-4, with specificity for mesenchymal precursor cells from human and ovine tissues. Gronthos S, et al. Stem Cells Dev, 2009 Nov. PMID 19327008

See all (582) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HSP90beta controls NLRP3 autoactivation.
    Title: HSP90β controls NLRP3 autoactivation.
  2. Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug prediction using virtual screening.
    Title: Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug prediction using virtual screening.
  3. Proliferation, migration, and resistance to oxidative and thermal stresses of HT1080 cells with knocked out genes encoding Hsp90alpha and Hsp90beta.
    Title: Proliferation, migration, and resistance to oxidative and thermal stresses of HT1080 cells with knocked out genes encoding Hsp90α and Hsp90β.
  4. HSP90beta prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
    Title: HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
  5. PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer.
    Title: PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer.
  6. Despite their structural similarities, the cytosolic isoforms of human Hsp90 show different behaviour in thermal unfolding due to their conformation: An FTIR study.
    Title: Despite their structural similarities, the cytosolic isoforms of human Hsp90 show different behaviour in thermal unfolding due to their conformation: An FTIR study.
  7. ALS-linked loss of Cyclin-F function affects HSP90.
    Title: ALS-linked loss of Cyclin-F function affects HSP90.
  8. HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma.
    Title: HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma.
  9. LncRNA RP3-326I13.1 promotes cisplatin resistance in lung adenocarcinoma by binding to HSP90B and upregulating MMP13.
    Title: LncRNA RP3-326I13.1 promotes cisplatin resistance in lung adenocarcinoma by binding to HSP90B and upregulating MMP13.
  10. CircVCAN/SUB1 up-regulates MYC/HSP90beta to enhance the proliferation and migration of glioma cells.
    Title: CircVCAN/SUB1 up-regulates MYC/HSP90β to enhance the proliferation and migration of glioma cells.
Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
Tat tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
tat Expression of HIV-1 Tat upregulates the abundance of heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1) in the nucleoli of Jurkat T-cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock protein 90kDa, class B member 1 (HSP90AB1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
capsid gag Reduced infectivity of HIV-1 CA mutants can be rescued by HSP90AB1 overexpression. Hyperthermia-induced expression of HSP90AB1 rescues CA-mutant infectivity in nonactivated cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1: beta; 84 kDa) at amino acid residues 483-484 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26984

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity TAS
Traceable Author Statement
more info
  
enables ATP-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables DNA polymerase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables MHC class II protein complex binding HDA PubMed 
enables RNA binding HDA PubMed 
enables TPR domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cadherin binding HDA PubMed 
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone methyltransferase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nitric-oxide synthase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein folding chaperone ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor ligand inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone-mediated protein complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in placenta development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to unfolded protein NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in supramolecular fiber organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomerase holoenzyme complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_positive_effect telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in virion attachment to host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HSP90-CDC37 chaperone complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of aryl hydrocarbon receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dynein axonemal particle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein folding chaperone complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
heat shock protein HSP 90-beta
Names
HSP90-beta
heat shock 84 kDa
heat shock 90kD protein 1, beta
heat shock protein 90 kDa
heat shock protein 90kDa alpha (cytosolic), class B member 1
heat shock protein 90kDa alpha family class B member 1
heat shock protein family C member 3

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271969.2 → NP_001258898.1  heat shock protein HSP 90-beta isoform a

    See identical proteins and their annotated locations for NP_001258898.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AY359878, BQ028821
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
    UniProtKB/TrEMBL
    B4DGL0
    Related
    ENSP00000325875.3, ENST00000353801.7
    Conserved Domains (1) summary
    PTZ00272
    Location:14 → 724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

  2. NM_001271970.2 → NP_001258899.1  heat shock protein HSP 90-beta isoform a

    See identical proteins and their annotated locations for NP_001258899.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
    Source sequence(s)
    BC004928, BE539681, BX420114, DC341882
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
    UniProtKB/TrEMBL
    B4DGL0
    Related
    ENSP00000481908.1, ENST00000620073.4
    Conserved Domains (1) summary
    PTZ00272
    Location:14 → 724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

  3. NM_001271971.2 → NP_001258900.1  heat shock protein HSP 90-beta isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and two alternate in-frame splice sides in the coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.
    Source sequence(s)
    BC004928, BE539681, BG482327, DC350708
    UniProtKB/TrEMBL
    B4DGL0
    Conserved Domains (2) summary
    PTZ00272
    Location:14 → 676
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:143 → 666
    HSP90; Hsp90 protein

  4. NM_001271972.2 → NP_001258901.1  heat shock protein HSP 90-beta isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and uses an alternate in-frame splice site in the internal coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
    Source sequence(s)
    AK294643, BC007327, BE539681
    UniProtKB/TrEMBL
    B4DGL0
    Conserved Domains (3) summary
    PTZ00272
    Location:14 → 714
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:181 → 704
    HSP90; Hsp90 protein
    pfam02518
    Location:40 → 178
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  5. NM_001371238.1 → NP_001358167.1  heat shock protein HSP 90-beta isoform a

    Status: REVIEWED

    Source sequence(s)
    AL139392
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
    UniProtKB/TrEMBL
    B4DGL0
    Related
    ENSP00000360609.1, ENST00000371554.2
    Conserved Domains (1) summary
    PTZ00272
    Location:14 → 724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

  6. NM_007355.4 → NP_031381.2  heat shock protein HSP 90-beta isoform a

    See identical proteins and their annotated locations for NP_031381.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
    Source sequence(s)
    BC004928, BE539681, DC340766
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
    UniProtKB/TrEMBL
    B4DGL0
    Related
    ENSP00000360709.5, ENST00000371646.10
    Conserved Domains (1) summary
    PTZ00272
    Location:14 → 724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    44246194..44253883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    44080360..44088031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_073528.1: Suppressed sequence

    Description
    NR_073528.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08238.4 GenPept UniProtKB/Swiss-Prot:P08238

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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