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Ipk2 Inositol phosphate kinase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33236, updated on 2-Nov-2024

Summary

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Official Symbol
Ipk2provided by FlyBase
Official Full Name
Inositol phosphate kinase 2provided by FlyBase
Primary source
FLYBASE:FBgn0031267
Locus tag
Dmel_CG13688
See related
AllianceGenome:FB:FBgn0031267
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13688; Dmel\CG13688; dmIpk2; ipk2
Summary
Enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; and inositol-1,4,5-trisphosphate 6-kinase activity. Involved in imaginal disc development and inositol phosphate biosynthetic process. Located in nucleoplasm. Is expressed in salivary gland. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Ipk2 in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (573033..574264, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (573033..574264, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Notchless Neighboring gene Splicing factor 3b subunit 1 Neighboring gene coiled Neighboring gene Prothoracicotropic hormone Neighboring gene PvuII-PstI homology 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development. Dean DM, et al. G3 (Bethesda), 2015 Nov 27. PMID 26613949, Free PMC Article
  2. Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila. Seeds AM, et al. Proc Natl Acad Sci U S A, 2015 Dec 22. PMID 26647185, Free PMC Article
  3. Cluster-Based Analysis of Retinitis Pigmentosa Modifiers Using Drosophila Eye Size and Gene Expression Data. Amstutz J, et al. Genes (Basel), 2022 Feb 21. PMID 35205430, Free PMC Article
  4. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
  5. PLA2G12A as a Novel Biomarker for Colorectal Cancer with Prognostic Relevance. Parisi E, et al. Int J Mol Sci, 2023 Jun 30. PMID 37446068, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables inositol tetrakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,4,5-trisphosphate 6-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in imaginal disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inositol phosphate kinase 2
Names
CG13688-PA
Ipk2-PA
NP_608535.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    573033..574264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134691.2 → NP_608535.1  inositol phosphate kinase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608535.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRX9, Q9VPR6
    Related
    FBpp0077734
    Conserved Domains (1) summary
    pfam03770
    Location:100 → 304
    IPK; Inositol polyphosphate kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRX9 Q8MRX9
Q9VPR6 Q9VPR6

Gene LinkOut

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