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rempA reduced mechanoreceptor potential A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33230, updated on 2-Nov-2024

Summary

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Official Symbol
rempAprovided by FlyBase
Official Full Name
reduced mechanoreceptor potential Aprovided by FlyBase
Primary source
FLYBASE:FBgn0260933
Locus tag
Dmel_CG11838
See related
AllianceGenome:FB:FBgn0260933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11838; Che-11; CHE-11; Dmel\CG11838; IFT140; IFT40; OSEG; oseg3; Oseg3; OSEG3; remp; RempA; REMPA
Summary
Involved in several processes, including non-motile cilium assembly; positive regulation of canonical Wnt signaling pathway; and transport along microtubule. Located in non-motile cilium. Is expressed in larval antenno-maxillary sensory complex; peripheral sensory precursor cell; sensory organ cell; and spermatozoon. Human ortholog(s) of this gene implicated in retinitis pigmentosa and short-rib thoracic dysplasia 9 with or without polydactyly. Orthologous to human IFT140 (intraflagellar transport 140). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See rempA in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (553742..560310, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (553742..560310, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor beta3 Neighboring gene Signal peptide peptidase Neighboring gene Ets at 21C Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene Translocator protein Neighboring gene uncharacterized protein Neighboring gene Notchless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TSPO, a Mitochondrial Outer Membrane Protein, Controls Ethanol-Related Behaviors in Drosophila. Lin R, et al. PLoS Genet, 2015 Aug. PMID 26241038, Free PMC Article
  2. Wg/Wnt-signaling-induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interference with the IFT-A complex. Vuong LT, et al. Cell Rep, 2024 Jun 25. PMID 38870008, Free PMC Article
  3. The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia in Drosophila. Sharma Y, et al. Front Mol Neurosci, 2023. PMID 37808471, Free PMC Article
  4. Novel tools to unravel molecular mechanisms in cilia-related disorders. Fliegauf M, et al. Trends Genet, 2006 May. PMID 16564109
  5. Genetic approaches to mechanosensory transduction. Kernan M, et al. Curr Opin Neurobiol, 1995 Aug. PMID 7488844

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary retrograde transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein import into nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein transport along microtubule IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
reduced mechanoreceptor potential A
Names
CG11838-PB
CG11838-PC
Oseg3
RempA
reduced mechanoreceptor potentials
reduced mechanoreceptor potentials A
rempA-PB
rempA-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    553742..560310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134686.2 → NP_608530.2  reduced mechanoreceptor potential A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608530.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1EC86, Q5BI64, Q9VPR0
    Conserved Domains (4) summary
    COG0457
    Location:815 → 1025
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG2319
    Location:26 → 435
    WD40; WD40 repeat [General function prediction only]
    sd00006
    Location:892 → 928
    TPR; TPR repeat [structural motif]
    cl14649
    Location:856 → 1065
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

  2. NM_205886.2 → NP_995608.1  reduced mechanoreceptor potential A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995608.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1EC86, Q7KTZ4
    Conserved Domains (6) summary
    COG0457
    Location:860 → 1070
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG2319
    Location:71 → 480
    WD40; WD40 repeat [General function prediction only]
    sd00006
    Location:937 → 973
    TPR; TPR repeat [structural motif]
    sd00039
    Location:67 → 103
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:14 → 123
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14649
    Location:901 → 1110
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KTZ4 Q7KTZ4
Q9VPR0 Q9VPR0

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