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Krt78 keratin 78 [ Mus musculus (house mouse) ]

Gene ID: 332131, updated on 2-Nov-2024

Summary

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Official Symbol
Krt78provided by MGI
Official Full Name
keratin 78provided by MGI
Primary source
MGI:MGI:1917529
See related
Ensembl:ENSMUSG00000050463 AllianceGenome:MGI:1917529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kb40; 2310030B04Rik
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Is active in cornified envelope. Orthologous to human KRT78 (keratin 78). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in stomach adult (RPKM 6.1), lung adult (RPKM 4.9) and 2 other tissues See more
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Genomic context

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See Krt78 in Genome Data Viewer
Location:
15 F2; 15 57.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101854436..101905059, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101946001..101996624, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 4 Neighboring gene keratin 79 Neighboring gene keratin 8 Neighboring gene predicted gene, 36026

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression. Langbein L, et al. Cell Tissue Res, 2016 Mar. PMID 26340985
  2. TERRA transcripts are bound by a complex array of RNA-binding proteins. López de Silanes I, et al. Nat Commun, 2010 Jun 29. PMID 20975687
  3. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. Kumar V, et al. J Cell Biol, 2015 Dec 7. PMID 26644517, Free PMC Article
  4. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
  5. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. K78 is strongly expressed in the basal and parabasal cell layers with decreasing intensity in the lower suprabasal cells of keratinising and non-keratinising squamous epithelia and keratinocyte cultures.
    Title: Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
keratin Kb40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212487.4 → NP_997652.4  keratin Kb40

    Status: VALIDATED

    Source sequence(s)
    AK146611, BK004080, BY792966
    Consensus CDS
    CCDS49736.1
    UniProtKB/TrEMBL
    E9Q0F0
    Related
    ENSMUSP00000126197.2, ENSMUST00000164932.3
    Conserved Domains (5) summary
    COG0845
    Location:272 → 590
    AcrA; Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms]
    cl21524
    Location:277 → 379
    PRK13923; putative spore coat protein regulator protein YlbO; Provisional
    pfam00038
    Location:104 → 417
    Filament; Intermediate filament protein
    pfam15272
    Location:167 → 314
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam16208
    Location:63 → 101
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101854436..101905059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245680.2 → XP_011243982.1  keratin Kb40 isoform X2

    Conserved Domains (3) summary
    COG0845
    Location:229 → 547
    AcrA; Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms]
    pfam09606
    Location:426 → 721
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00038
    Location:61 → 374
    Filament; Intermediate filament protein

  2. XM_006521114.4 → XP_006521177.1  keratin Kb40 isoform X1

    Conserved Domains (4) summary
    COG0845
    Location:358 → 676
    AcrA; Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms]
    pfam09606
    Location:555 → 850
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00038
    Location:190 → 503
    Filament; Intermediate filament protein
    pfam16208
    Location:147 → 187
    Keratin_2_head; Keratin type II head
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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