U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mapk15 mitogen-activated protein kinase 15 [ Mus musculus (house mouse) ]

Gene ID: 332110, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Mapk15provided by MGI
Official Full Name
mitogen-activated protein kinase 15provided by MGI
Primary source
MGI:MGI:2652894
See related
Ensembl:ENSMUSG00000063704 AllianceGenome:MGI:2652894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERK-8
Summary
Predicted to enable MAP kinase activity and chromatin binding activity. Involved in positive regulation of metaphase/anaphase transition of meiosis I; positive regulation of spindle assembly; and regulation of cilium assembly. Located in meiotic spindle. Is expressed in several structures, including brain; genitourinary system; limb; nose; and viscerocranium. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 48.8), lung adult (RPKM 26.9) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15 D3; 15 35.2 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75865581..75871002)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75993732..75999153)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 707 Neighboring gene coiled-coil domain containing 166 Neighboring gene family with sequence similarity 83, member H Neighboring gene IQ motif and ankyrin repeat containing 1 Neighboring gene scribbled planar cell polarity Neighboring gene microRNA 6952

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The distribution and possible role of ERK8 in mouse oocyte meiotic maturation and early embryo cleavage. Yang SW, et al. Microsc Microanal, 2013 Feb. PMID 23351492
  2. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. Xu YM, et al. Cancer Res, 2010 Apr 15. PMID 20395206
  3. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. Iavarone C, et al. J Biol Chem, 2006 Apr 14. PMID 16484222
  4. ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled. Miyatake K, et al. Nat Commun, 2015 Mar 31. PMID 25823377
  5. Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity. Rossi M, et al. J Biol Chem, 2011 Mar 11. PMID 21190936, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage.
    Title: The distribution and possible role of ERK8 in mouse oocyte meiotic maturation and early embryo cleavage.
  2. a novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor.
    Title: Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.
  3. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer
    Title: Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
  4. Erk8 has a role as a novel effector of RET/PTC3 and, therefore, RET biological functions
    Title: Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC56865, MGC56903

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in dopamine uptake ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of metaphase/anaphase transition of meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of COPII vesicle coating ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mitogen-activated protein kinase 15
Names
ERK-7
MAP kinase 15
MAPK 15
extracellular signal-regulated kinase 7
extracellular signal-regulated kinase 8
NP_001403335.1
NP_001403336.1
NP_001403337.1
NP_808590.1
XP_006521162.1
XP_006521163.1
XP_006521164.1
XP_006521165.1
XP_006521166.1
XP_006521167.1
XP_006521169.1
XP_011243980.1
XP_011243981.1
XP_017172159.1
XP_017172160.1
XP_030104475.1
XP_030104476.1
XP_036015365.1
XP_036015366.1
XP_036015367.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416406.1 → NP_001403335.1  mitogen-activated protein kinase 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116487

  2. NM_001416407.1 → NP_001403336.1  mitogen-activated protein kinase 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116487

  3. NM_001416408.1 → NP_001403337.1  mitogen-activated protein kinase 15 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116487

  4. NM_177922.3 → NP_808590.1  mitogen-activated protein kinase 15 isoform 1

    See identical proteins and their annotated locations for NP_808590.1

    Status: VALIDATED

    Source sequence(s)
    AC116487
    Consensus CDS
    CCDS27558.1
    UniProtKB/Swiss-Prot
    Q80Y86
    Related
    ENSMUSP00000087098.5, ENSMUST00000089669.6
    Conserved Domains (2) summary
    smart00220
    Location:14 → 305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:6 → 344
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75865581..75871002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521104.4 → XP_006521167.1  mitogen-activated protein kinase 15 isoform X6

    See identical proteins and their annotated locations for XP_006521167.1

    Conserved Domains (1) summary
    cd07852
    Location:6 → 374
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

  2. XM_006521103.3 → XP_006521166.1  mitogen-activated protein kinase 15 isoform X6

    See identical proteins and their annotated locations for XP_006521166.1

    Conserved Domains (1) summary
    cd07852
    Location:6 → 374
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

  3. XM_006521106.3 → XP_006521169.1  mitogen-activated protein kinase 15 isoform X8

    Conserved Domains (1) summary
    cd07852
    Location:6 → 344
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

  4. XM_006521099.3 → XP_006521162.1  mitogen-activated protein kinase 15 isoform X1

    Conserved Domains (1) summary
    cd07852
    Location:6 → 374
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

  5. XM_006521101.3 → XP_006521164.1  mitogen-activated protein kinase 15 isoform X3

    Conserved Domains (1) summary
    cd07852
    Location:6 → 364
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

  6. XM_011245678.4 → XP_011243980.1  mitogen-activated protein kinase 15 isoform X12

  7. XM_011245679.4 → XP_011243981.1  mitogen-activated protein kinase 15 isoform X13

  8. XM_006521100.3 → XP_006521163.1  mitogen-activated protein kinase 15 isoform X2

    Conserved Domains (1) summary
    cd07852
    Location:6 → 374
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

  9. XM_006521102.3 → XP_006521165.1  mitogen-activated protein kinase 15 isoform X4

    Conserved Domains (1) summary
    cd07852
    Location:6 → 344
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

  10. XM_030248615.2 → XP_030104475.1  mitogen-activated protein kinase 15 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:58 → 237
    PKc_like; Protein Kinases, catalytic domain

  11. XM_030248616.2 → XP_030104476.1  mitogen-activated protein kinase 15 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:58 → 237
    PKc_like; Protein Kinases, catalytic domain

  12. XM_036159473.1 → XP_036015366.1  mitogen-activated protein kinase 15 isoform X9

    Conserved Domains (1) summary
    cl21453
    Location:58 → 207
    PKc_like; Protein Kinases, catalytic domain

  13. XM_017316671.3 → XP_017172160.1  mitogen-activated protein kinase 15 isoform X14

    Conserved Domains (1) summary
    cl21453
    Location:58 → 207
    PKc_like; Protein Kinases, catalytic domain

  14. XM_017316670.3 → XP_017172159.1  mitogen-activated protein kinase 15 isoform X9

    Conserved Domains (1) summary
    cl21453
    Location:58 → 207
    PKc_like; Protein Kinases, catalytic domain

  15. XM_036159474.1 → XP_036015367.1  mitogen-activated protein kinase 15 isoform X10

    Conserved Domains (1) summary
    cl21453
    Location:58 → 207
    PKc_like; Protein Kinases, catalytic domain

  16. XM_036159472.1 → XP_036015365.1  mitogen-activated protein kinase 15 isoform X9

    Conserved Domains (1) summary
    cl21453
    Location:58 → 207
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_384020.3 RNA Sequence

  2. XR_004938843.1 RNA Sequence

  3. XR_004938844.1 RNA Sequence

  4. XR_004938845.1 RNA Sequence

  5. XR_003951401.2 RNA Sequence

  6. XR_004938846.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80Y86.1 GenPept UniProtKB/Swiss-Prot:Q80Y86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools