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hsd17b12a hydroxysteroid (17-beta) dehydrogenase 12a [ Danio rerio (zebrafish) ]

Gene ID: 327417, updated on 12-Sep-2024

Summary

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Official Symbol
hsd17b12aprovided by ZNC
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 12aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5628
See related
Ensembl:ENSDARG00000015709 AllianceGenome:ZFIN:ZDB-GENE-030131-5628
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
KAR; fi06g11; zgc:55589; zgc:77599; wu:fi06g11
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in estrogen biosynthetic process and fatty acid biosynthetic process. Predicted to act upstream of or within steroid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including EVL; digestive system; integument; nervous system; and pleuroperitoneal region. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See hsd17b12a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (30196055..30230559)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (29753048..29787552)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene apoptosis inhibitor 5 Neighboring gene si:ch211-147k10.6 Neighboring gene microRNA mir-129-4 Neighboring gene alkB homolog 3, alpha-ketoglutarate dependent dioxygenase Neighboring gene si:ch1073-281m9.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and characterization of 17 beta-hydroxysteroid dehydrogenases in the zebrafish, Danio rerio. Mindnich R, et al. Mol Cell Endocrinol, 2004 Feb 27. PMID 15026171
  2. Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2. Tokarz J, et al. Mol Cell Endocrinol, 2012 Feb 26. PMID 22061621
  3. Transcriptomic analysis of zebrafish (Danio rerio) embryos to assess integrated biotoxicity of Xitiaoxi River waters. Zhou S, et al. Environ Pollut, 2018 Nov. PMID 29958174
  4. Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Li Z, et al. Environ Pollut, 2020 Jul. PMID 32146360
  5. Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (Epinephelus coioides): Genome-Wide Identification and Expression Analysis During Sex Reversal. Xiao L, et al. Front Genet, 2020. PMID 32194632, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain 3-oxoacyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in estrogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
very-long-chain 3-oxoacyl-CoA reductase-A
Names
17-beta hydroxysteroid dehydrogenase type 12A, 3-ketoacyl-CoA reductase type A
17-beta-HSD 12-A
17-beta-hydroxysteroid dehydrogenase 12-A
3-ketoacyl-CoA reductase
estradiol 17-beta-dehydrogenase 12-A
zf 3.1
zf3.1
zfHSD17B12A
NP_957175.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200881.1 → NP_957175.1  very-long-chain 3-oxoacyl-CoA reductase-A

    See identical proteins and their annotated locations for NP_957175.1

    Status: PROVISIONAL

    Source sequence(s)
    BC063943
    UniProtKB/Swiss-Prot
    Q6P3L6, Q7ZUN4
    Related
    ENSDARP00000014003.8, ENSDART00000005299.10
    Conserved Domains (2) summary
    PLN02780
    Location:18 → 310
    PLN02780; ketoreductase/ oxidoreductase
    cd05356
    Location:56 → 288
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    30196055..30230559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P3L6.1 GenPept UniProtKB/Swiss-Prot:Q6P3L6

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