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kcnd3 potassium voltage-gated channel, Shal-related subfamily, member 3 [ Danio rerio (zebrafish) ]

Gene ID: 327415, updated on 2-Nov-2024

Summary

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Official Symbol
kcnd3provided by ZNC
Official Full Name
potassium voltage-gated channel, Shal-related subfamily, member 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5626
See related
Ensembl:ENSDARG00000056101 AllianceGenome:ZFIN:ZDB-GENE-030131-5626
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55306; wu:fi06g01
Summary
Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion transmembrane transport. Predicted to be located in cell projection and membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendritic spine; neuronal cell body; and postsynaptic membrane. Is expressed in heart and nervous system. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See kcnd3 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (28066074..28236472)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (28046738..28217333)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene CTTNBP2 N-terminal like b Neighboring gene uncharacterized LOC137490329 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 Neighboring gene RAP1A, member of RAS oncogene family a Neighboring gene inka box actin regulator 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional and pharmacological characterization of a Shal-related K+ channel subunit in Zebrafish. Nakamura TY, et al. BMC Physiol, 2008 Feb 8. PMID 18261223, Free PMC Article
  2. Analysis and functional evaluation of the hair-cell transcriptome. McDermott BM Jr, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17606911, Free PMC Article
  3. Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5-cryab-hspb2 signalling in zebrafish. Gou D, et al. Acta Physiol (Oxf), 2021 Mar. PMID 33032360
  4. Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. Yang S, et al. Int J Mol Sci, 2022 Jul 7. PMID 35886872, Free PMC Article
  5. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables A-type (transient outward) potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A-type voltage-gated potassium channel KCND3
Names
potassium voltage-gated channel, Shal-related family, member 3
zShal3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199802.1 → NP_956096.1  A-type voltage-gated potassium channel KCND3

    See identical proteins and their annotated locations for NP_956096.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045304
    UniProtKB/TrEMBL
    A0A8M1PBW8, Q7ZW36
    Related
    ENSDARP00000072994.4, ENSDART00000078533.5
    Conserved Domains (6) summary
    smart00225
    Location:42 → 139
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:213 → 411
    Ion_trans; Ion transport protein
    pfam02214
    Location:42 → 131
    BTB_2; BTB/POZ domain
    pfam07885
    Location:327 → 407
    Ion_trans_2; Ion channel
    pfam11601
    Location:3 → 28
    Shal-type; Shal-type voltage-gated potassium channels
    pfam11879
    Location:443 → 544
    DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    28066074..28236472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167002.5 → XP_005167059.1  A-type voltage-gated potassium channel KCND3 isoform X1

    UniProtKB/TrEMBL
    A0A286Y962, A0A8M2BEB5
    Related
    ENSDARP00000143711.1, ENSDART00000178481.2
    Conserved Domains (6) summary
    smart00225
    Location:42 → 139
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:213 → 411
    Ion_trans; Ion transport protein
    pfam02214
    Location:42 → 131
    BTB_2; BTB/POZ domain
    pfam07885
    Location:327 → 407
    Ion_trans_2; Ion channel
    pfam11601
    Location:3 → 28
    Shal-type; Shal-type voltage-gated potassium channels
    pfam11879
    Location:443 → 556
    DUF3399; Domain of unknown function (DUF3399)

  2. XM_005167003.5 → XP_005167060.1  A-type voltage-gated potassium channel KCND3 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BF04
    Conserved Domains (6) summary
    smart00225
    Location:42 → 139
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:213 → 411
    Ion_trans; Ion transport protein
    pfam02214
    Location:42 → 131
    BTB_2; BTB/POZ domain
    pfam07885
    Location:327 → 407
    Ion_trans_2; Ion channel
    pfam11601
    Location:3 → 28
    Shal-type; Shal-type voltage-gated potassium channels
    pfam11879
    Location:443 → 555
    DUF3399; Domain of unknown function (DUF3399)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395273.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    248556..263573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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