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tho2 tho2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326153, updated on 18-Sep-2024

Summary

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Official Symbol
tho2provided by FlyBase
Official Full Name
tho2provided by FlyBase
Primary source
FLYBASE:FBgn0031390
Locus tag
Dmel_CG31671
See related
AllianceGenome:FB:FBgn0031390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31671; CG4263; Dmel\CG31671; macadamia; Tho2; THO2; Thoc2
Summary
Predicted to enable mRNA binding activity. Involved in mRNA export from nucleus in response to heat stress and oogenesis. Located in nucleus. Part of THO complex. Is expressed in egg chamber. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See tho2 in Genome Data Viewer
Location:
22D1-22D1; 2-5 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2137350..2145187, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2137350..2145187, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glycogen phosphorylase Neighboring gene uncharacterized protein Neighboring gene Tubulin-binding cofactor D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article
  2. ENY2 protein forms a part of the THO complex of Drosophila melanogaster. Gurskiy DY, et al. Dokl Biochem Biophys, 2010 Jul-Aug. PMID 20714859
  3. A systems view of mRNP biology. Hieronymus H, et al. Genes Dev, 2004 Dec 1. PMID 15574591
  4. A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary. ElMaghraby MF, et al. Genetics, 2022 Jan 4. PMID 34718559, Free PMC Article
  5. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Le Thomas A, et al. Genes Dev, 2013 Feb 15. PMID 23392610, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus in response to heat stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of THO complex IEA
Inferred from Electronic Annotation
more info
  
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription export complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tho2
Names
CG31671-PA
CG31671-PB
CG31671-PC
tho2-PA
tho2-PB
tho2-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2137350..2145187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164454.2 → NP_722763.1  tho2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722763.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQ76
    Related
    FBpp0077525
    Conserved Domains (4) summary
    pfam11262
    Location:939 → 1240
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:629 → 703
    Thoc2; Transcription- and export-related complex subunit
    pfam12871
    Location:1569 → 1638
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16134
    Location:133 → 627
    THOC2_N; THO complex subunit 2 N-terminus

  2. NM_001272976.1 → NP_001259905.1  tho2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259905.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE28
    Conserved Domains (4) summary
    pfam11262
    Location:939 → 1240
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:629 → 703
    Thoc2; Transcription- and export-related complex subunit
    pfam12871
    Location:1569 → 1638
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16134
    Location:133 → 627
    THOC2_N; THO complex subunit 2 N-terminus

  3. NM_134802.4 → NP_608646.3  tho2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608646.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCS8
    Conserved Domains (4) summary
    pfam11262
    Location:939 → 1240
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:629 → 703
    Thoc2; Transcription- and export-related complex subunit
    pfam12871
    Location:1570 → 1639
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16134
    Location:133 → 627
    THOC2_N; THO complex subunit 2 N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QCS8 E2QCS8
M9PE28 M9PE28
Q960L4 Q960L4
Q9VQ76 Q9VQ76

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