hhip hedgehog interacting protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hhipprovided by ZNC
Official Full Name: hedgehog interacting proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4827
See related: Ensembl:ENSDARG00000060397 AllianceGenome:ZFIN:ZDB-GENE-030131-4827
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fd99f01; wu:fc52e12; wu:fd99f01; zgc:153478
Summary: Acts upstream of or within fin development; negative regulation of muscle organ development; and negative regulation of smoothened signaling pathway. Located in plasma membrane. Is expressed in several structures, including axis; mesoderm; muscle cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (hedgehog interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (35790082..35835863)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (35058055..35103836)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hhip regulates muscle development both by sequestering Hedgehog and by modulating localization of Smoothened
Title: Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.

Submit: New GeneRIF Correction

General gene information

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Markers

fd99f01.x1 (e-PCR)
- UniSTS:195875

G48095 (e-PCR)
- UniSTS:108859

AW165053 (e-PCR)
- UniSTS:205889

G39750 (e-PCR)
- UniSTS:48454

fc52e12 (e-PCR)
- UniSTS:189314

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of muscle organ development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of muscle organ development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hedgehog-interacting protein

Names: Hip; uki; ukkie

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080012.1 → NP_001073481.1 hedgehog-interacting protein precursor

See identical proteins and their annotated locations for NP_001073481.1

Status: PROVISIONAL

Source sequence(s)

BC128659

UniProtKB/TrEMBL

A1A5I0

Related

ENSDARP00000079486.4, ENSDART00000085051.5

Conserved Domains (2) summary

pfam03024
Location:36 → 212

Folate_rec; Folate receptor family

pfam07995
Location:218 → 420

GSDH; Glucose / Sorbosone dehydrogenase