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CycD Cyclin D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32551, updated on 18-Sep-2024

Summary

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Official Symbol
CycDprovided by FlyBase
Official Full Name
Cyclin Dprovided by FlyBase
Primary source
FLYBASE:FBgn0010315
Locus tag
Dmel_CG9096
See related
AllianceGenome:FB:FBgn0010315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cdi3; Cdi3; CDI3; CG9096; Cyc D; Cyc-D; cycD; CYCD; cyclin D; cyclinD; dCycD; DmcycD; Dmel\CG9096
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of cell growth; positive regulation of signal transduction; and regulation of mitochondrion organization. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in embryonic/larval midgut; eye-antennal disc; imaginal disc; morphogenetic furrow; and organism. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ductal carcinoma in situ; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to several human genes including CCND1 (cyclin D1) and CCND2 (cyclin D2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CycD in Genome Data Viewer
Location:
13F18-14A1; 1-52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15906822..15909676, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15800855..15803709, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene shibire Neighboring gene LDL receptor related protein 4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Live cell cycle analysis of Drosophila tissues using the Attune Acoustic Focusing Cytometer and Vybrant DyeCycle violet DNA stain. Flegel K, et al. J Vis Exp, 2013 May 19. PMID 23712023, Free PMC Article
  2. Conversion of quiescent niche cells to somatic stem cells causes ectopic niche formation in the Drosophila testis. Hétié P, et al. Cell Rep, 2014 May 8. PMID 24746819, Free PMC Article
  3. [Phase-specific elements of the regulatory zone of the Drosophila melanogaster string gene]. Trunova SA, et al. Genetika, 2001 Dec. PMID 11785287
  4. Epigenetic alterations induced by aflatoxin B(1): An in vitro and in vivo approach with emphasis on enhancer of zeste homologue-2/p21 axis. Soni P, et al. Sci Total Environ, 2021 Mar 25. PMID 33131875
  5. Sexual Dimorphism of Body Size Is Controlled by Dosage of the X-Chromosomal Gene Myc and by the Sex-Determining Gene tra in Drosophila. Mathews KW, et al. Genetics, 2017 Mar. PMID 28064166, Free PMC Article

See all (189) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
    Title: Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.
  2. The results indicate that the precise regulation of neuronal CycD activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.
    Title: Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress.
  3. Loss of Cyclin D increase L-Lactate dehydrigenase protein in normoxia.
    Title: Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress.
  4. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue
    Title: Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4.
  5. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.
    Title: Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.
  6. mRpL12 is required for CycD/Cdk4-induced cell growth
    Title: The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth.
  7. Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos
    Title: Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitochondrion organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin D
Names
CG9096-PD
CG9096-PE
CG9096-PF
CycD-PD
CycD-PE
CycD-PF
Cyclin-dependent kinase interactor 3
cyclinD
dCyclinD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15906822..15909676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078631.4 → NP_523355.2  cyclin D, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523355.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUZ5, Q9VXM1
    Conserved Domains (2) summary
    pfam00134
    Location:155 → 280
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:282 → 392
    Cyclin_C; Cyclin, C-terminal domain

  2. NM_167472.3 → NP_727912.2  cyclin D, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727912.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUZ5, Q9VXM1
    Conserved Domains (2) summary
    pfam00134
    Location:155 → 280
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:282 → 392
    Cyclin_C; Cyclin, C-terminal domain

  3. NM_167473.2 → NP_727913.2  cyclin D, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727913.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUZ5, Q9VXM1
    Conserved Domains (2) summary
    pfam00134
    Location:155 → 280
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:282 → 392
    Cyclin_C; Cyclin, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24158 Q24158
Q7KUZ5 Q7KUZ5
Q9GTQ8 Q9GTQ8
Q9VXM1 Q9VXM1

Gene LinkOut

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