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Pis Phosphatidylinositol synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32506, updated on 18-Sep-2024

Summary

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Official Symbol
Pisprovided by FlyBase
Official Full Name
Phosphatidylinositol synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0030670
Locus tag
Dmel_CG9245
See related
AllianceGenome:FB:FBgn0030670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO02059370.38; CG9245; Dmel\CG9245; dpis; dPis; dPIS; PIS
Summary
Enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity. Involved in basement membrane organization and phototransduction. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including adult heart; embryonic brain; embryonic/larval nervous system; extended germ band embryo; and eye. Orthologous to human CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pis in Genome Data Viewer
Location:
13E8-13E8; 1-51 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15701451..15703770, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15595484..15597803, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Huntingtin-associated protein 40 kDa Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila. Laurinyecz B, et al. Open Biol, 2016 Jan. PMID 26791243, Free PMC Article
  2. A phosphoinositide synthase required for a sustained light response. Wang T, et al. J Neurosci, 2006 Dec 6. PMID 17151285, Free PMC Article
  3. Evidence of sinks and sources in the phospholipase C-activated PIP(2) cycle. Suratekar R, et al. FEBS Lett, 2018 Mar. PMID 29427502
  4. Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells. Devergne O, et al. Cell Rep, 2017 Feb 21. PMID 28228250, Free PMC Article
  5. CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway. Liu Y, et al. PLoS Genet, 2014 Mar. PMID 24603715, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pis regulates the polarized deposition of basement membrane proteins.
    Title: Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol synthase
Names
CG9245-PA
CG9245-PB
PI synthase
Phosphatidyl-inositol synthase
Pis-PA
Pis-PB
drosophila phosphatidylinositol synthase
NP_573055.1
NP_727878.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15701451..15703770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132827.3 → NP_573055.1  phosphatidylinositol synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573055.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F3YDD4, Q8IR29, Q8SX37, Q9VXR7
    Related
    FBpp0073874
    Conserved Domains (1) summary
    pfam01066
    Location:13 → 75
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  2. NM_167456.3 → NP_727878.1  phosphatidylinositol synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727878.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9YHX2
    Related
    FBpp0073875
    Conserved Domains (1) summary
    pfam01066
    Location:13 → 63
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SX37.1 Q8SX37

Gene LinkOut

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